San Francisco 49ers and Los Angeles Rams Tied 1-1 Head-to-Head (2025-26)

NFL1-1-0 ATS (50%)Updated November 9, 2025

The San Francisco 49ers are 1-1 against the Los Angeles Rams in 2025-26 in head-to-head matchups, going 1-1-0 ATS (50% cover rate) with -0.98% ROI. Games average 58.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

49ers vs Rams Betting Record — 2025-26

Against the Spread

1-1-0

Win %

50%

ROI

-0.98%

Units

-0.0

Moneyline

1-1-0

Win %

50%

ROI

+120%

Units

+2.4

Over Rate

2-0-0

Win %

100%

ROI

+90.1%

Units

+1.8

From the Other Side — Rams vs 49ers

Against the Spread

1-1-0

Win %

50%

ROI

-6.52%

Units

-0.1

Moneyline

1-1-0

Win %

50%

ROI

-30.62%

Units

-0.6

Over Rate

2-0-0

Win %

100%

ROI

+90.1%

Units

+1.8

Venue Splits

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Rams Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

49ers

PPG

32.5

allowed

Total

58.5

Avg

games

Rams

32.5

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/092025-11-09	Rams @ 49ers	L 26-42	-5.5	✗	L	O
10/022025-10-02	49ers @ Rams	W 23-26	-7.5	✓	W	O

Frequently Asked Questions

What is the San Francisco 49ers vs Los Angeles Rams 2025-26 record?

The San Francisco 49ers are 1-1 against the Los Angeles Rams in 2025-26 in head-to-head matchups.

What is the San Francisco 49ers ATS record vs the Los Angeles Rams?

The San Francisco 49ers are 1-1-0 against the spread vs the Los Angeles Rams in 2025-26 on DraftKings, with -0.98% ROI.

Do San Francisco 49ers vs Los Angeles Rams games go over or under?

San Francisco 49ers vs Los Angeles Rams games average 58.5 total points in 2025-26. The Over has hit 100% of the time.

More 49ers Matchups

vs Cardinals

vs Seahawks

See from Rams perspective

Head-to-head betting record for San Francisco 49ers vs Los Angeles Rams in the 2025-26 season on LineTerminal. The 49ers are 1-1 straight up against the Rams and 1-1-0 against the spread (50% cover rate, -0.98% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.