RamsAway42
49ersHome26SpreadMissFav -5.5
MoneylineLoss
TotalOver49.5
NFL · Head to head
49ers vs Rams
2025-26 seasonLast meeting Nov 9, 2025
Betting comparison
2025-26
49ers
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- -0.98%
- Units
- -0.02u
Rams
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- -6.52%
- Units
- -0.13u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average points49ers26
Rams32.5
Combined58.5
Recent meetings
Bet results from the 49ers perspective. Spread values show the favorite’s closing line.
RamsAway4249ersHome2649ersAway26RamsHome23SpreadCoverFav -7.5
MoneylineWin
TotalOver43.5
More 49ers matchups
About this matchup
What is the San Francisco 49ers vs Los Angeles Rams 2025-26 record?
The San Francisco 49ers are 1-1 against the Los Angeles Rams in 2025-26 in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Los Angeles Rams?
The San Francisco 49ers are 1-1-0 against the spread vs the Los Angeles Rams in 2025-26 on DraftKings, with -0.98% ROI.
Do San Francisco 49ers vs Los Angeles Rams games go over or under?
San Francisco 49ers vs Los Angeles Rams games average 58.5 total points in 2025-26. The Over has hit 100% of the time.