San Francisco 49ers Lead Arizona Cardinals 2-0 in Head-to-Head Matchups (2025-26)

NFL1-1-0 ATS (50%)Updated November 16, 2025

The San Francisco 49ers are 2-0 against the Arizona Cardinals in 2025-26 in head-to-head matchups, going 1-1-0 ATS (50% cover rate) with 0% ROI. Games average 47 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

49ers vs Cardinals Betting Record — 2025-26

Against the Spread

1-1-0

Win %

50%

ROI

Units

0.0

Moneyline

2-0-0

Win %

100%

ROI

+67.03%

Units

+1.3

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

From the Other Side — Cardinals vs 49ers

Against the Spread

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

Venue Splits

49ers Home

0-1-0 ATS

0% • -100%

1-0-0 ML (100%)

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

49ers

28.5

PPG

18.5

allowed

Total

Avg

games

Cardinals

18.5

PPG

28.5

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/162025-11-16	49ers @ Cardinals	W 22-41	-3.5	✓	W	O
09/212025-09-21	Cardinals @ 49ers	W 16-15	-1.5	✗	W	U

Frequently Asked Questions

What is the San Francisco 49ers vs Arizona Cardinals 2025-26 record?

The San Francisco 49ers are 2-0 against the Arizona Cardinals in 2025-26 in head-to-head matchups.

What is the San Francisco 49ers ATS record vs the Arizona Cardinals?

The San Francisco 49ers are 1-1-0 against the spread vs the Arizona Cardinals in 2025-26 on DraftKings, with 0% ROI.

Do San Francisco 49ers vs Arizona Cardinals games go over or under?

San Francisco 49ers vs Arizona Cardinals games average 47 total points in 2025-26. The Over has hit 50% of the time.

More 49ers Matchups

vs Rams

vs Seahawks

See from Cardinals perspective

Head-to-head betting record for San Francisco 49ers vs Arizona Cardinals in the 2025-26 season on LineTerminal. The 49ers are 2-0 straight up against the Cardinals and 1-1-0 against the spread (50% cover rate, 0% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.