49ersAway41
CardinalsHome22SpreadCoverFav -3.5
MoneylineWin
TotalOver48.5
NFL · Head to head
49ers vs Cardinals
2025-26 seasonLast meeting Nov 16, 2025
Betting comparison
2025-26
49ers
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- 0%
- Units
- 0u
Cardinals
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- -5.36%
- Units
- -0.11u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average points49ers28.5
Cardinals18.5
Combined47
Recent meetings
Bet results from the 49ers perspective. Spread values show the favorite’s closing line.
49ersAway41CardinalsHome22CardinalsAway1549ersHome16SpreadMissFav -1.5
MoneylineWin
TotalUnder44.5
More 49ers matchups
About this matchup
What is the San Francisco 49ers vs Arizona Cardinals 2025-26 record?
The San Francisco 49ers are 2-0 against the Arizona Cardinals in 2025-26 in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Arizona Cardinals?
The San Francisco 49ers are 1-1-0 against the spread vs the Arizona Cardinals in 2025-26 on DraftKings, with 0% ROI.
Do San Francisco 49ers vs Arizona Cardinals games go over or under?
San Francisco 49ers vs Arizona Cardinals games average 47 total points in 2025-26. The Over has hit 50% of the time.