San Francisco 49ers Lead Arizona Cardinals 2-0 in Head-to-Head Matchups (2025-26)

NFL1-1-0 ATS (50%)Updated November 16, 2025

The Arizona Cardinals are 0-2 against the San Francisco 49ers in 2025-26 in head-to-head matchups, going 1-1-0 ATS (50% cover rate) with -5.36% ROI. Games average 47 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

Cardinals vs 49ers Betting Record — 2025-26

Against the Spread

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

From the Other Side — 49ers vs Cardinals

Against the Spread

1-1-0

Win %

50%

ROI

Units

0.0

Moneyline

2-0-0

Win %

100%

ROI

+67.03%

Units

+1.3

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

Venue Splits

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

49ers Home

0-1-0 ATS

0% • -100%

1-0-0 ML (100%)

Scoring Averages

Cardinals

18.5

PPG

28.5

allowed

Total

Avg

games

49ers

28.5

PPG

18.5

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/162025-11-16	49ers @ Cardinals	L 22-41	-3.5	✗	L	O
09/212025-09-21	Cardinals @ 49ers	L 16-15	-1.5	✓	L	U

Frequently Asked Questions

What is the Arizona Cardinals vs San Francisco 49ers 2025-26 record?

The Arizona Cardinals are 0-2 against the San Francisco 49ers in 2025-26 in head-to-head matchups.

What is the Arizona Cardinals ATS record vs the San Francisco 49ers?

The Arizona Cardinals are 1-1-0 against the spread vs the San Francisco 49ers in 2025-26 on DraftKings, with -5.36% ROI.

Do Arizona Cardinals vs San Francisco 49ers games go over or under?

Arizona Cardinals vs San Francisco 49ers games average 47 total points in 2025-26. The Over has hit 50% of the time.

More Cardinals Matchups

vs Rams

vs Seahawks

See from 49ers perspective

Head-to-head betting record for Arizona Cardinals vs San Francisco 49ers in the 2025-26 season on LineTerminal. The Cardinals are 0-2 straight up against the 49ers and 1-1-0 against the spread (50% cover rate, -5.36% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.