CardinalsAway30
49ersHome36SpreadCoverFav -7.5
MoneylineLoss
TotalOver48.5
NFL · Head to head
Cardinals vs 49ers
All recorded seasonsLast meeting Sep 27, 2026
Betting comparison
All seasons
Cardinals
13 bets7-6-0Wins · Losses · Pushes
- Win rate
- 53.85%
- ROI
- +2.14%
- Units
- +0.28u
49ers
13 bets6-7-0Wins · Losses · Pushes
- Win rate
- 46.15%
- ROI
- -11.44%
- Units
- -1.49u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsCardinals22.3
49ers27.9
Combined50.2
Recent meetings
Bet results from the Cardinals perspective. Spread values show the favorite’s closing line.
CardinalsAway3049ersHome3649ersAway41CardinalsHome22SpreadMissFav -3.5
MoneylineLoss
TotalOver48.5
CardinalsAway1549ersHome16SpreadCoverFav -1.5
MoneylineLoss
TotalUnder44.5
49ersAway24CardinalsHome47SpreadCoverFav -4.5
MoneylineWin
TotalOver43.5
CardinalsAway2449ersHome23SpreadCoverFav -7.5
MoneylineWin
TotalUnder49
More Cardinals matchups
About this matchup
What is the Arizona Cardinals vs San Francisco 49ers all-time record?
The Arizona Cardinals are 5-8 against the San Francisco 49ers in head-to-head matchups.
What is the Arizona Cardinals ATS record vs the San Francisco 49ers?
The Arizona Cardinals are 7-6-0 against the spread vs the San Francisco 49ers on DraftKings, with +2.14% ROI.
Do Arizona Cardinals vs San Francisco 49ers games go over or under?
Arizona Cardinals vs San Francisco 49ers games average 50.2 total points. The Over has hit 61.54% of the time.