Inside Edge
MLB Odds Today — Friday, May 22, 2026
15 MLB games on the board for Friday, May 22, 2026, with the largest favorite at Chicago Cubs −1.5. Spreads, moneyline, and over/under from DraftKings, with closing-line ATS and total results once games complete.
See methodology for grading rules and ROI calculation.
MLB Odds & Schedule
Scores, odds, and results for every MLB game.
Upcoming15
1:21 PM
O/U 7
Astros+1.5+123
Cubs-1.5-148
5:41 PM
O/U 9.5
Cardinals-1.5+104
Reds+1.5-126
5:41 PM
O/U 6.5
Guardians+1.5+153
Phillies-1.5-186
6:06 PM
O/U 8
Rays+1.5+123
Yankees-1.5-149
6:08 PM
O/U 8
Pirates+1.5+135
Blue Jays-1.5-163
6:11 PM
O/U 7.5
Twins+1.5+129
Red Sox-1.5-156
6:11 PM
O/U 8
Mets-1.5-105
Marlins+1.5-114
6:15 PM
O/U 9
Nationals+1.5+178
Braves-1.5-219
6:16 PM
O/U 8.5
Tigers+1.5+119
Orioles-1.5-143
6:41 PM
O/U 8
Mariners-1.5-119
Royals+1.5-102
6:41 PM
O/U 8.5
Dodgers-1.5-110
Brewers+1.5-109
8:39 PM
O/U 7.5
Rangers-1.5-168
Angels+1.5+139
8:41 PM
O/U 9
Rockies+1.5+178
Diamondbacks-1.5-218
8:41 PM
O/U 7.5
Athletics+1.5+109
Padres-1.5-131
9:16 PM
O/U 7
White Sox-1.5-114
Giants+1.5-105