NFL Odds Today — Thursday, October 22, 2026
14 NFL games on the board for Thursday, October 22, 2026, with the largest favorite at Houston Texans −10. Spreads, moneyline, and over/under from DraftKings, with closing-line ATS and total results once games complete.
See methodology for grading rules and ROI calculation.
NFL · Live OddsNFL Schedule
Scores, odds, and results for every NFL game.
Thursday, Oct 221
Sunday, Oct 2512
8:30 AM
O/U 44.5
Steelers-3.5-185
Saints+3.5+154
12:00 PM
O/U 49.5
49ers-3.5-205
Falcons+3.5+170
12:00 PM
O/U 38.5
Browns-1.5-125
Titans+1.5+105
12:00 PM
O/U 41.5
Colts+6.5+225
Vikings-6.5-278
12:00 PM
O/U 38.5
Dolphins+4.5+190
Jets-4.5-230
12:00 PM
O/U 44.5
Buccaneers+3.5+154
Panthers-3.5-185
12:00 PM
O/U 51.5
Bengals+3+130
Ravens-3-155
12:00 PM
O/U 42.5
Giants+10+380
Texans-10-500
3:05 PM
O/U 43.5
Broncos-4.5-230
Cardinals+4.5+190
3:25 PM
O/U 53.5
Packers+3+140
Lions-3-166
3:25 PM
O/U 47.5
Rams-4.5-225
Raiders+4.5+185
7:20 PM
O/U 42.5
Chiefs+2.5+114
Seahawks-2.5-135
Monday, Oct 261
