49ers vs Cardinals Betting Record
Against the Spread
6-6-0
Win %
50%
ROI
-4.06%
Units
-0.5
Moneyline
7-5-0
Win %
58.33%
ROI
-7.47%
Units
-0.9
Over Rate
7-5-0
Win %
58.33%
ROI
+11.91%
Units
+1.4
From the Other Side — Cardinals vs 49ers
Against the Spread
6-6-0
Win %
50%
ROI
-5.26%
Units
-0.6
Moneyline
5-7-0
Win %
41.67%
ROI
+10.41%
Units
+1.3
Over Rate
7-5-0
Win %
58.33%
ROI
+11.91%
Units
+1.4
Venue Splits
49ers Home
2-4-0 ATS
33.33% • -36.63%
3-3-0 ML (50%)
Cardinals Home
2-4-0 ATS
33.33% • -36.63%
2-4-0 ML (33.33%)
Scoring Averages
49ers
27.3
PPG
21.7
allowed
Total
48.9
Avg
12
games
Cardinals
21.7
PPG
27.3
allowed
Recent Matchups
| Date | Score | ATS | ML | O/U |
|---|---|---|---|---|
| 11/162025-11-16 | W 22-41 | ✓ | W | O |
| 09/212025-09-21 | W 16-15 | ✗ | W | U |
| 01/052025-01-05 | L 47-24 | ✗ | L | O |
| 10/062024-10-06 | L 23-24 | ✗ | L | U |
| 12/172023-12-17 | W 29-45 | ✓ | W | O |
| 10/012023-10-01 | W 35-16 | ✓ | W | O |
| 01/082023-01-08 | W 38-13 | ✓ | W | O |
| 11/212022-11-21 | W 10-38 | ✓ | W | O |
| 11/072021-11-07 | L 17-31 | ✗ | L | O |
| 10/102021-10-10 | L 17-10 | ✗ | L | U |
| 12/262020-12-26 | W 12-20 | ✓ | W | U |
| 09/132020-09-13 | L 20-24 | ✗ | L | U |
Frequently Asked Questions
What is the San Francisco 49ers vs Arizona Cardinals all-time record?
The San Francisco 49ers are 7-5 against the Arizona Cardinals in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Arizona Cardinals?
The San Francisco 49ers are 6-6-0 against the spread vs the Arizona Cardinals on DraftKings, with -4.06% ROI.
Do San Francisco 49ers vs Arizona Cardinals games go over or under?
San Francisco 49ers vs Arizona Cardinals games average 48.9 total points. The Over has hit 58.33% of the time.
Inside Edge