CardinalsAway30
49ersHome36SpreadMissFav -7.5
MoneylineWin
TotalOver48.5
NFL · Head to head
49ers vs Cardinals
All recorded seasonsLast meeting Sep 27, 2026
Betting comparison
All seasons
49ers
13 bets6-7-0Wins · Losses · Pushes
- Win rate
- 46.15%
- ROI
- -11.44%
- Units
- -1.49u
Cardinals
13 bets7-6-0Wins · Losses · Pushes
- Win rate
- 53.85%
- ROI
- +2.14%
- Units
- +0.28u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average points49ers27.9
Cardinals22.3
Combined50.2
Recent meetings
Bet results from the 49ers perspective. Spread values show the favorite’s closing line.
CardinalsAway3049ersHome3649ersAway41CardinalsHome22SpreadCoverFav -3.5
MoneylineWin
TotalOver48.5
CardinalsAway1549ersHome16SpreadMissFav -1.5
MoneylineWin
TotalUnder44.5
49ersAway24CardinalsHome47SpreadMissFav -4.5
MoneylineLoss
TotalOver43.5
CardinalsAway2449ersHome23SpreadMissFav -7.5
MoneylineLoss
TotalUnder49
More 49ers matchups
About this matchup
What is the San Francisco 49ers vs Arizona Cardinals all-time record?
The San Francisco 49ers are 8-5 against the Arizona Cardinals in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Arizona Cardinals?
The San Francisco 49ers are 6-7-0 against the spread vs the Arizona Cardinals on DraftKings, with -11.44% ROI.
Do San Francisco 49ers vs Arizona Cardinals games go over or under?
San Francisco 49ers vs Arizona Cardinals games average 50.2 total points. The Over has hit 61.54% of the time.