49ersAway27
RamsHome7SpreadCoverFav -3.5
MoneylineWin
TotalUnder47.5
NFL · Head to head
49ers vs Rams
All recorded seasonsLast meeting Sep 10, 2026
Betting comparison
All seasons
49ers
14 bets9-5-0Wins · Losses · Pushes
- Win rate
- 64.29%
- ROI
- +23.77%
- Units
- +3.33u
Rams
14 bets5-9-0Wins · Losses · Pushes
- Win rate
- 35.71%
- ROI
- -33.22%
- Units
- -4.65u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average points49ers24
Rams19.1
Combined43.1
Recent meetings
Bet results from the 49ers perspective. Spread values show the favorite’s closing line.
49ersAway27RamsHome7RamsAway4249ersHome26SpreadMissFav -5.5
MoneylineLoss
TotalOver49.5
49ersAway26RamsHome23SpreadCoverFav -7.5
MoneylineWin
TotalOver43.5
RamsAway1249ersHome6SpreadMissFav -3
MoneylineLoss
TotalUnder48.5
49ersAway24RamsHome27SpreadMissFav -6
MoneylineLoss
TotalOver44.5
More 49ers matchups
About this matchup
What is the San Francisco 49ers vs Los Angeles Rams all-time record?
The San Francisco 49ers are 9-5 against the Los Angeles Rams in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Los Angeles Rams?
The San Francisco 49ers are 9-5-0 against the spread vs the Los Angeles Rams on DraftKings, with +23.77% ROI.
Do San Francisco 49ers vs Los Angeles Rams games go over or under?
San Francisco 49ers vs Los Angeles Rams games average 43.1 total points. The Over has hit 50% of the time.