49ers vs Rams Betting Record
Against the Spread
8-5-0
Win %
61.54%
ROI
+18.27%
Units
+2.4
Moneyline
8-5-0
Win %
61.54%
ROI
+52.24%
Units
+6.8
Over Rate
7-6-0
Win %
53.85%
ROI
+3.47%
Units
+0.5
From the Other Side — Rams vs 49ers
Against the Spread
5-8-0
Win %
38.46%
ROI
-28.08%
Units
-3.6
Moneyline
5-8-0
Win %
38.46%
ROI
-14.26%
Units
-1.9
Over Rate
7-6-0
Win %
53.85%
ROI
+3.47%
Units
+0.5
Venue Splits
49ers Home
3-3-0 ATS
50% • -4.09%
3-3-0 ML (50%)
Rams Home
2-5-0 ATS
28.57% • -46.25%
2-5-0 ML (28.57%)
Scoring Averages
49ers
23.8
PPG
20.1
allowed
Total
43.8
Avg
13
games
Rams
20.1
PPG
23.8
allowed
Recent Matchups
| Date | Score | ATS | ML | O/U |
|---|---|---|---|---|
| 11/092025-11-09 | L 26-42 | ✗ | L | O |
| 10/022025-10-02 | W 23-26 | ✓ | W | O |
| 12/122024-12-12 | L 6-12 | ✗ | L | U |
| 09/222024-09-22 | L 27-24 | ✗ | L | O |
| 01/072024-01-07 | L 20-21 | ✗ | L | O |
| 09/172023-09-17 | W 23-30 | ✗ | W | O |
| 10/302022-10-30 | W 14-31 | ✓ | W | O |
| 10/032022-10-03 | W 24-9 | ✓ | W | U |
| 01/302022-01-30 | L 20-17 | ✓ | L | U |
| 01/092022-01-09 | W 24-27 | ✓ | W | O |
| 11/152021-11-15 | W 31-10 | ✓ | W | U |
| 11/292020-11-29 | W 20-23 | ✓ | W | U |
| 10/182020-10-18 | W 24-16 | ✓ | W | U |
Frequently Asked Questions
What is the San Francisco 49ers vs Los Angeles Rams all-time record?
The San Francisco 49ers are 8-5 against the Los Angeles Rams in head-to-head matchups.
What is the San Francisco 49ers ATS record vs the Los Angeles Rams?
The San Francisco 49ers are 8-5-0 against the spread vs the Los Angeles Rams on DraftKings, with +18.27% ROI.
Do San Francisco 49ers vs Los Angeles Rams games go over or under?
San Francisco 49ers vs Los Angeles Rams games average 43.8 total points. The Over has hit 53.85% of the time.
Inside Edge