49ersAway27
RamsHome7SpreadMissFav -3.5
MoneylineLoss
TotalUnder47.5
NFL · Head to head
Rams vs 49ers
All recorded seasonsLast meeting Sep 10, 2026
Betting comparison
All seasons
Rams
14 bets5-9-0Wins · Losses · Pushes
- Win rate
- 35.71%
- ROI
- -33.22%
- Units
- -4.65u
49ers
14 bets9-5-0Wins · Losses · Pushes
- Win rate
- 64.29%
- ROI
- +23.77%
- Units
- +3.33u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsRams19.1
49ers24
Combined43.1
Recent meetings
Bet results from the Rams perspective. Spread values show the favorite’s closing line.
49ersAway27RamsHome7RamsAway4249ersHome26SpreadCoverFav -5.5
MoneylineWin
TotalOver49.5
49ersAway26RamsHome23SpreadMissFav -7.5
MoneylineLoss
TotalOver43.5
RamsAway1249ersHome6SpreadCoverFav -3
MoneylineWin
TotalUnder48.5
49ersAway24RamsHome27SpreadCoverFav -6
MoneylineWin
TotalOver44.5
More Rams matchups
About this matchup
What is the Los Angeles Rams vs San Francisco 49ers all-time record?
The Los Angeles Rams are 5-9 against the San Francisco 49ers in head-to-head matchups.
What is the Los Angeles Rams ATS record vs the San Francisco 49ers?
The Los Angeles Rams are 5-9-0 against the spread vs the San Francisco 49ers on DraftKings, with -33.22% ROI.
Do Los Angeles Rams vs San Francisco 49ers games go over or under?
Los Angeles Rams vs San Francisco 49ers games average 43.1 total points. The Over has hit 50% of the time.