San Francisco 49ers Betting Record — 2025-26
Against the Spread
12-7-0
Win%
63.16%
ROI
+21.48%
Units
+4.1
Moneyline
13-6-0
Win%
68.42%
ROI
+28.07%
Units
+5.3
Over Rate
11-8-0
Win%
57.89%
ROI
+11.28%
Units
+2.1
49ers Monthly Performance
+21.6%12-7 · +4.1u
-5%
-0.5%
+54.2%
+89.3%
-36.4%
Sep
2-2
2-2
Oct
2-2
2-2
Nov
4-1
4-1
Dec
3-0
3-0
Jan
1-2
1-2
Top Betting AngleMin. 10 games
49ers As Favorite ATS: 10-2-0
Win %: 83.33%ROI: +59.93%12 games
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49ers Home / Away Splits
Home
ATSAgainst the Spread
4-4-0-4.02%
MLMoneyline
5-3-0-6.05%
O/UOver Rate
4-4-0-4.74%
Away
ATSAgainst the Spread
8-3-0+40.03%
MLMoneyline
8-3-0+52.88%
O/UOver Rate
7-4-0+22.93%
49ers as Favorite / Underdog
As Favorite
ATSAgainst the Spread
10-2-0+59.93%
MLMoneyline
11-1-0+40.69%
As Underdog
ATSAgainst the Spread
2-5-0-44.44%
MLMoneyline
2-5-0+6.43%
Betting Against the 49ers
What happens when you fade the 49ers and bet on their opponent every game?
Fade Against the Spread
7-12-0
Win%
36.84%
ROI
-30.88%
Units
-5.9
Fade Moneyline
6-13-0
Win%
31.58%
ROI
-47.26%
Units
-9.0
49ers Recent Games
| Date | Opponent | Score | ATS | ML | O/U |
|---|---|---|---|---|---|
| 2026-01-17 |  @ Seahawks | L 41-6 | ✗ | L | O |
| 2026-01-11 |  @ Eagles | W 19-23 | ✓ | W | U |
| 2026-01-03 | vs Seahawks | L 3-13 | ✗ | L | U |
| 2025-12-28 |  vs Bears | W 42-38 | ✓ | W | O |
| 2025-12-22 |  @ Colts | W 27-48 | ✓ | W | O |
| 2025-12-14 |  vs Titans | W 37-24 | ✓ | W | O |
| 2025-11-30 |  @ Browns | W 8-26 | ✓ | W | U |
| 2025-11-24 |  vs Panthers | W 20-9 | ✓ | W | U |
| 2025-11-16 |  @ Cardinals | W 22-41 | ✓ | W | O |
| 2025-11-09 |  vs Rams | L 26-42 | ✗ | L | O |
49ers Head-to-Head Matchups
NFC West Standings
| Moneyline | ATS | Over/Under | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| # | Team | Record | Win% | ROI | Record | Win% | ROI | Record | Win% | ROI |
| 1 |  SEASeahawks | 17-3-0 | 85% | +29.13% | 15-5-0 | 75% | +44.3% | 11-9-0 | 55% | +4.43% |
| 2 |  LARRams | 14-6-0 | 70% | -4.37% | 12-8-0 | 60% | +14.52% | 12-8-0 | 60% | +12.92% |
| 3 |  SF49ers | 13-6-0 | 68.42% | +28.07% | 12-7-0 | 63.16% | +21.48% | 11-8-0 | 57.89% | +11.28% |
| 4 |  ARICardinals | 3-14-0 | 17.65% | -69.75% | 6-11-0 | 35.29% | -32.59% | 10-7-0 | 58.82% | +13.11% |
Frequently Asked Questions
What is the San Francisco 49ers record against the spread?
The San Francisco 49ers were 12-7-0 against the spread in 2025-26 on DraftKings, with a 63.16% cover rate and +21.48% ROI.
What is the San Francisco 49ers home and away ATS record?
At home, the San Francisco 49ers were 4-4-0 ATS (-4.02% ROI). On the road, they were 8-3-0 ATS (+40.03% ROI).
How did the San Francisco 49ers performed as favorites vs underdogs ATS?
As favorites, the San Francisco 49ers were 10-2-0 ATS (83.33% cover rate). As underdogs, they were 2-5-0 ATS (28.57% cover rate).
What is the San Francisco 49ers moneyline record?
The San Francisco 49ers were 13-6-0 straight up (moneyline) in 2025-26, with a 68.42% win rate and +28.07% ROI on DraftKings.
Inside Edge