The San Francisco 49ers are 10-2-0 ATS as Favorites in 2025-26
NFLNFC • NFC West
The San Francisco 49ers are 10-2-0 as favorite in 2025-26, a 83.33% rate with +59.93% ROI on flat $100 bets at closing odds. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.
Favorite ATS
10-2-0
Win %
83.33%
ROI
+59.93%
Games
12
Favorite ML
11-1-0
Win %
91.67%
ROI
+40.69%
Games
12
49ers Monthly Performance
+21.6%12-7 · +4.1u
-5%
-0.5%
+54.2%
+89.3%
-36.4%
Sep
2-2
2-2
Oct
2-2
2-2
Nov
4-1
4-1
Dec
3-0
3-0
Jan
1-2
1-2
Home / Away as Favorite ATS
Home
4-2-0
66.67%+27.98%
Away
6-0-0
100%+91.89%
Recent Games (2025-26)
| Date | Opponent | Score | ATS | ML | O/U |
|---|---|---|---|---|---|
| 2026-01-17 |  @ Seahawks | L 41-6 | ✗ | L | O |
| 2026-01-11 |  @ Eagles | W 19-23 | ✓ | W | U |
| 2026-01-03 | vs Seahawks | L 3-13 | ✗ | L | U |
| 2025-12-28 |  vs Bears | W 42-38 | ✓ | W | O |
| 2025-12-22 |  @ Colts | W 27-48 | ✓ | W | O |
| 2025-12-14 |  vs Titans | W 37-24 | ✓ | W | O |
| 2025-11-30 |  @ Browns | W 8-26 | ✓ | W | U |
| 2025-11-24 |  vs Panthers | W 20-9 | ✓ | W | U |
| 2025-11-16 |  @ Cardinals | W 22-41 | ✓ | W | O |
| 2025-11-09 |  vs Rams | L 26-42 | ✗ | L | O |
Frequently Asked Questions
What is the San Francisco 49ers as favorite in 2025-26?
The San Francisco 49ers are 10-2-0 (83.33%) as favorite in 2025-26 on DraftKings, with +59.93% ROI.
What is the San Francisco 49ers home vs away as favorite?
Home: 4-2-0 (+27.98% ROI). Away: 6-0-0 (+91.89% ROI).
More 49ers Stats (2025-26)
Compare As Favorite
Record as Favorite for the San Francisco 49ers in the 2025-26 season on LineTerminal. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results. LineTerminal offers advanced system-building tools to research San Francisco 49ers betting trends across 80+ filters and 5+ years of data.
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