- Win rate
- 83.33%
- ROI
- +59.93%
- Graded games
- 12
NFL · NFC · NFC West
San Francisco 49ers As Favorite
- Win rate
- 91.67%
- ROI
- +40.69%
- Graded games
- 12
Only games with recorded DraftKings moneyline odds are included.
49ers Monthly performance
+89.3%Dec · 3-0
-5%
+100%
+92.8%
+89.3%
Sep
2-2
2-2
Oct
1-0
1-0
Nov
4-0
4-0
Dec
3-0
3-0
Home / Away as Favorite ATS
Home
4-2-0
66.67%+27.98%
Away
6-0-0
100%+91.89%
Recent Games (2025-26)
| Date | Opponent | Score | ATS | ML | O/U |
|---|---|---|---|---|---|
| 2025-12-28 |  vs Bears | W 42-38 | ✓ | W | O |
| 2025-12-22 |  @ Colts | W 48-27 | ✓ | W | O |
| 2025-12-14 |  vs Titans | W 37-24 | ✓ | W | O |
| 2025-11-30 |  @ Browns | W 26-8 | ✓ | W | U |
| 2025-11-24 |  vs Panthers | W 20-9 | ✓ | W | U |
| 2025-11-16 |  @ Cardinals | W 41-22 | ✓ | W | O |
| 2025-11-02 |  @ Giants | W 34-24 | ✓ | W | O |
| 2025-10-19 |  vs Falcons | W 20-10 | ✓ | W | U |
| 2025-09-28 |  vs Jaguars | L 21-26 | ✗ | L | O |
| 2025-09-21 | vs Cardinals | W 16-15 | ✗ | W | U |
Frequently Asked Questions
What is the San Francisco 49ers as favorite in 2025-26?
The San Francisco 49ers are 10-2-0 (83.33%) as favorite in 2025-26 on DraftKings, with +59.93% ROI.
What is the San Francisco 49ers home vs away as favorite?
Home: 4-2-0 (+27.98% ROI). Away: 6-0-0 (+91.89% ROI).
More 49ers Stats (2025-26)
Compare As Favorite
Data and season archive
Records use DraftKings closing lines and each market’s graded sample. Win rates exclude pushes; ROI uses flat one-unit bets. Each split can have a different sample. Latest recorded game: 2025-12-28.