Seattle Seahawks Lead San Francisco 49ers 2-1 in Head-to-Head Matchups (2025-26)

NFL1-2-0 ATS (33.33%)Updated January 17, 2026

The San Francisco 49ers are 1-2 against the Seattle Seahawks in 2025-26 in head-to-head matchups, going 1-2-0 ATS (33.33% cover rate) with -36.9% ROI. Games average 31 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

49ers vs Seahawks Betting Record — 2025-26

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

Moneyline

1-2-0

Win %

33.33%

ROI

-43.19%

Units

-1.3

Over Rate

1-2-0

Win %

33.33%

ROI

-33.99%

Units

-1.0

From the Other Side — Seahawks vs 49ers

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.78%

Units

+0.8

Moneyline

2-1-0

Win %

66.67%

ROI

-1.08%

Units

-0.0

Over Rate

1-2-0

Win %

33.33%

ROI

-33.99%

Units

-1.0

Venue Splits

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Seahawks Home

1-1-0 ATS

50% • 0%

1-1-0 ML (50%)

Scoring Averages

49ers

8.7

PPG

22.3

allowed

Total

Avg

games

Seahawks

22.3

PPG

8.7

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
01/172026-01-17	49ers @ Seahawks	L 41-6	-7	✗	L	O
01/032026-01-03	Seahawks @ 49ers	L 3-13	-2.5	✗	L	U
09/072025-09-07	49ers @ Seahawks	W 13-17	-2.5	✓	W	U

Frequently Asked Questions

What is the San Francisco 49ers vs Seattle Seahawks 2025-26 record?

The San Francisco 49ers are 1-2 against the Seattle Seahawks in 2025-26 in head-to-head matchups.

What is the San Francisco 49ers ATS record vs the Seattle Seahawks?

The San Francisco 49ers are 1-2-0 against the spread vs the Seattle Seahawks in 2025-26 on DraftKings, with -36.9% ROI.

Do San Francisco 49ers vs Seattle Seahawks games go over or under?

San Francisco 49ers vs Seattle Seahawks games average 31 total points in 2025-26. The Over has hit 33.33% of the time.

More 49ers Matchups

vs Cardinals

vs Rams

See from Seahawks perspective

Head-to-head betting record for San Francisco 49ers vs Seattle Seahawks in the 2025-26 season on LineTerminal. The 49ers are 1-2 straight up against the Seahawks and 1-2-0 against the spread (33.33% cover rate, -36.9% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.