Seattle Seahawks Lead San Francisco 49ers 2-1 in Head-to-Head Matchups (2025-26)

NFL2-1-0 ATS (66.67%)Updated January 17, 2026

The Seattle Seahawks are 2-1 against the San Francisco 49ers in 2025-26 in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +27.78% ROI. Games average 31 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

Seahawks vs 49ers Betting Record — 2025-26

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.78%

Units

+0.8

Moneyline

2-1-0

Win %

66.67%

ROI

-1.08%

Units

-0.0

Over Rate

1-2-0

Win %

33.33%

ROI

-33.99%

Units

-1.0

From the Other Side — 49ers vs Seahawks

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

Moneyline

1-2-0

Win %

33.33%

ROI

-43.19%

Units

-1.3

Over Rate

1-2-0

Win %

33.33%

ROI

-33.99%

Units

-1.0

Venue Splits

Seahawks Home

1-1-0 ATS

50% • 0%

1-1-0 ML (50%)

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Seahawks

22.3

PPG

8.7

allowed

Total

Avg

games

49ers

8.7

PPG

22.3

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
01/172026-01-17	49ers @ Seahawks	W 41-6	-7	✓	W	O
01/032026-01-03	Seahawks @ 49ers	W 3-13	-2.5	✓	W	U
09/072025-09-07	49ers @ Seahawks	L 13-17	-2.5	✗	L	U

Frequently Asked Questions

What is the Seattle Seahawks vs San Francisco 49ers 2025-26 record?

The Seattle Seahawks are 2-1 against the San Francisco 49ers in 2025-26 in head-to-head matchups.

What is the Seattle Seahawks ATS record vs the San Francisco 49ers?

The Seattle Seahawks are 2-1-0 against the spread vs the San Francisco 49ers in 2025-26 on DraftKings, with +27.78% ROI.

Do Seattle Seahawks vs San Francisco 49ers games go over or under?

Seattle Seahawks vs San Francisco 49ers games average 31 total points in 2025-26. The Over has hit 33.33% of the time.

More Seahawks Matchups

vs Cardinals

vs Rams

See from 49ers perspective

Head-to-head betting record for Seattle Seahawks vs San Francisco 49ers in the 2025-26 season on LineTerminal. The Seahawks are 2-1 straight up against the 49ers and 2-1-0 against the spread (66.67% cover rate, +27.78% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.