RamsAway42
49ersHome26SpreadCoverFav -5.5
MoneylineWin
TotalOver49.5
NFL · Head to head
Rams vs 49ers
2025-26 seasonLast meeting Nov 9, 2025
Betting comparison
2025-26
Rams
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- -6.52%
- Units
- -0.13u
49ers
2 bets1-1-0Wins · Losses · Pushes
- Win rate
- 50%
- ROI
- -0.98%
- Units
- -0.02u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsRams32.5
49ers26
Combined58.5
Recent meetings
Bet results from the Rams perspective. Spread values show the favorite’s closing line.
RamsAway4249ersHome2649ersAway26RamsHome23SpreadMissFav -7.5
MoneylineLoss
TotalOver43.5
More Rams matchups
About this matchup
What is the Los Angeles Rams vs San Francisco 49ers 2025-26 record?
The Los Angeles Rams are 1-1 against the San Francisco 49ers in 2025-26 in head-to-head matchups.
What is the Los Angeles Rams ATS record vs the San Francisco 49ers?
The Los Angeles Rams are 1-1-0 against the spread vs the San Francisco 49ers in 2025-26 on DraftKings, with -6.52% ROI.
Do Los Angeles Rams vs San Francisco 49ers games go over or under?
Los Angeles Rams vs San Francisco 49ers games average 58.5 total points in 2025-26. The Over has hit 100% of the time.