Los Angeles Rams and San Francisco 49ers Tied 1-1 Head-to-Head (2025-26)

NFL1-1-0 ATS (50%)Updated November 9, 2025

The Los Angeles Rams are 1-1 against the San Francisco 49ers in 2025-26 in head-to-head matchups, going 1-1-0 ATS (50% cover rate) with -6.52% ROI. Games average 58.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

Rams vs 49ers Betting Record — 2025-26

Against the Spread

1-1-0

Win %

50%

ROI

-6.52%

Units

-0.1

Moneyline

1-1-0

Win %

50%

ROI

-30.62%

Units

-0.6

Over Rate

2-0-0

Win %

100%

ROI

+90.1%

Units

+1.8

From the Other Side — 49ers vs Rams

Against the Spread

1-1-0

Win %

50%

ROI

-0.98%

Units

-0.0

Moneyline

1-1-0

Win %

50%

ROI

+120%

Units

+2.4

Over Rate

2-0-0

Win %

100%

ROI

+90.1%

Units

+1.8

Venue Splits

Rams Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Rams

32.5

PPG

allowed

Total

58.5

Avg

games

49ers

PPG

32.5

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/092025-11-09	Rams @ 49ers	W 26-42	-5.5	✓	W	O
10/022025-10-02	49ers @ Rams	L 23-26	-7.5	✗	L	O

Frequently Asked Questions

What is the Los Angeles Rams vs San Francisco 49ers 2025-26 record?

The Los Angeles Rams are 1-1 against the San Francisco 49ers in 2025-26 in head-to-head matchups.

What is the Los Angeles Rams ATS record vs the San Francisco 49ers?

The Los Angeles Rams are 1-1-0 against the spread vs the San Francisco 49ers in 2025-26 on DraftKings, with -6.52% ROI.

Do Los Angeles Rams vs San Francisco 49ers games go over or under?

Los Angeles Rams vs San Francisco 49ers games average 58.5 total points in 2025-26. The Over has hit 100% of the time.

More Rams Matchups

vs Cardinals

vs Seahawks

See from 49ers perspective

Head-to-head betting record for Los Angeles Rams vs San Francisco 49ers in the 2025-26 season on LineTerminal. The Rams are 1-1 straight up against the 49ers and 1-1-0 against the spread (50% cover rate, -6.52% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.