St. Louis Cardinals Lead Chicago Cubs 4-2 in Head-to-Head Matchups (2026)

MLB4-2-0 ATS (66.67%)Updated 3 days ago

The St. Louis Cardinals are 4-2 against the Chicago Cubs in 2026 in head-to-head matchups, going 4-2-0 ATS (66.67% cover rate) with +7.24% ROI. Games average 9.2 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.

See methodology.

Cardinals vs Cubs Betting Record — 2026

Against the Spread

4-2-0

Win %

66.67%

ROI

+7.24%

Units

+0.4

Moneyline

4-2-0

Win %

66.67%

ROI

+42.06%

Units

+2.5

Over Rate

3-3-0

Win %

50%

ROI

-6.19%

Units

-0.4

From the Other Side — Cubs vs Cardinals

Against the Spread

2-4-0

Win %

33.33%

ROI

-19.5%

Units

-1.2

Moneyline

2-4-0

Win %

33.33%

ROI

-42.29%

Units

-2.5

Over Rate

3-3-0

Win %

50%

ROI

-6.19%

Units

-0.4

Venue Splits

Cardinals Home

2-1-0 ATS

66.67% • +6.29%

2-1-0 ML (66.67%)

Cubs Home

1-2-0 ATS

33.33% • -15.33%

1-2-0 ML (33.33%)

Scoring Averages

Cardinals

PPG

3.2

allowed

Total

9.2

Avg

games

Cubs

3.2

PPG

allowed

Recent Matchups (2026)

Date	Matchup	Score	Spread	ATS	ML	O/U
07/052026-07-05	Cardinals @ Cubs	L 6-4	-1.5	✗	L	O
07/042026-07-04	Cardinals @ Cubs	W 0-3	-1.5	✓	W	U
07/032026-07-03	Cardinals @ Cubs	W 1-17	-1.5	✓	W	O
05/312026-05-31	Cubs @ Cardinals	W 5-1	-1.5	✓	W	U
05/302026-05-30	Cubs @ Cardinals	L 1-6	-1.5	✗	L	U
05/292026-05-29	Cubs @ Cardinals	W 6-5	-1.5	✓	W	O

Frequently Asked Questions

What is the St. Louis Cardinals vs Chicago Cubs 2026 record?

The St. Louis Cardinals are 4-2 against the Chicago Cubs in 2026 in head-to-head matchups.

What is the St. Louis Cardinals ATS record vs the Chicago Cubs?

The St. Louis Cardinals are 4-2-0 against the spread vs the Chicago Cubs in 2026 on DraftKings, with +7.24% ROI.

Do St. Louis Cardinals vs Chicago Cubs games go over or under?

St. Louis Cardinals vs Chicago Cubs games average 9.2 total points in 2026. The Over has hit 50% of the time.

More Cardinals Matchups

vs Reds

vs Brewers

vs Pirates

See from Cubs perspective

Head-to-head betting record for St. Louis Cardinals vs Chicago Cubs in the 2026 season on LineTerminal. The Cardinals are 4-2 straight up against the Cubs and 4-2-0 against the spread (66.67% cover rate, +7.24% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.