CardinalsAway0
CubsHome2Run lineMissFav -1.5
MoneylineLoss
TotalUnder7
MLB · Head to head
Cardinals vs Cubs
2025 seasonLast meeting Sep 28, 2025
Betting comparison
2025
Cardinals
13 bets5-8-0Wins · Losses · Pushes
- Win rate
- 38.46%
- ROI
- -35.96%
- Units
- -4.67u
Cubs
13 bets8-5-0Wins · Losses · Pushes
- Win rate
- 61.54%
- ROI
- +34.66%
- Units
- +4.51u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average runsCardinals3.1
Cubs6.2
Combined9.2
Recent meetings
Bet results from the Cardinals perspective. Spread values show the favorite’s closing line.
CardinalsAway0CubsHome2CardinalsAway3CubsHome7Run lineMissFav -1.5
MoneylineLoss
TotalOver9.5
CardinalsAway1CubsHome12Run lineMissFav -1.5
MoneylineLoss
TotalOver9
CubsAway2CardinalsHome3Run lineCoverFav -1.5
MoneylineWin
TotalUnder7.5
CubsAway9CardinalsHome1Run lineMissFav -1.5
MoneylineLoss
TotalOver9
More Cardinals matchups
About this matchup
What is the St. Louis Cardinals vs Chicago Cubs 2025 record?
The St. Louis Cardinals are 5-8 against the Chicago Cubs in 2025 in head-to-head matchups.
What is the St. Louis Cardinals ATS record vs the Chicago Cubs?
The St. Louis Cardinals are 5-8-0 against the spread vs the Chicago Cubs in 2025 on DraftKings, with -35.96% ROI.
Do St. Louis Cardinals vs Chicago Cubs games go over or under?
St. Louis Cardinals vs Chicago Cubs games average 9.2 total runs in 2025. The Over has hit 61.54% of the time.