Milwaukee Brewers Lead St. Louis Cardinals 7-6 in Head-to-Head Matchups (2025)

MLB8-5-0 ATS (61.54%)Data through 2025-09-21

Cardinals vs Brewers Betting Record — 2025

Against the Spread
8-5-0
Win %
61.54%
ROI
+0.92%
Units
+0.1
Moneyline
6-7-0
Win %
46.15%
ROI
-5.12%
Units
-0.7
Over Rate
5-7-1
Win %
41.67%
ROI
-20.59%
Units
-2.5

From the Other Side — Brewers vs Cardinals

Against the Spread
5-8-0
Win %
38.46%
ROI
-28.57%
Units
-3.7
Moneyline
7-6-0
Win %
53.85%
ROI
-7.72%
Units
-1.0
Over Rate
5-7-1
Win %
41.67%
ROI
-20.59%
Units
-2.5

Venue Splits

Cardinals Home
3-3-0 ATS
50% • -16.41%
4-2-0 ML (66.67%)
Brewers Home
2-5-0 ATS
28.57% • -48.25%
5-2-0 ML (71.43%)

Scoring Averages

Cardinals
3.8
PPG
4.2
allowed
Total
8
Avg
13
games
Brewers
4.2
PPG
3.8
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/21W 5-1WU
09/20L 2-3LU
09/19W 7-1WO
09/14W 2-3WU
09/13L 9-8LO
09/12L 8-2LO
06/15L 3-2LU
06/14W 5-8WO
06/13L 3-2LU
06/12L 6-0LU
04/27L 1-7LP
04/26W 6-5WO
04/25W 3-2WU

Frequently Asked Questions

What is the St. Louis Cardinals vs Milwaukee Brewers all-time record?
The St. Louis Cardinals are 6-7 against the Milwaukee Brewers in 2025 in head-to-head matchups.
What is the St. Louis Cardinals ATS record vs the Milwaukee Brewers?
The St. Louis Cardinals are 8-5-0 against the spread vs the Milwaukee Brewers in 2025 on DraftKings, with +0.92% ROI.
Do St. Louis Cardinals vs Milwaukee Brewers games go over or under?
St. Louis Cardinals vs Milwaukee Brewers games average 8 total points in 2025. The Over has hit 41.67% of the time.

More Cardinals Matchups

Head-to-head betting record for St. Louis Cardinals vs Milwaukee Brewers in the 2025 season on LineTerminal. The Cardinals are 6-7 straight up against the Brewers and 8-5-0 against the spread (61.54% cover rate, +0.92% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

LineTerminal

AI-powered betting intelligence for NBA, NHL, MLB, and NCAAB.

LineTerminal provides sports data and analytics for informational and entertainment purposes only. LineTerminal does not accept, place, or facilitate bets or wagers of any kind. Odds data is sourced from third-party providers and may not reflect exact lines at every sportsbook. Past performance does not guarantee future results. Sports betting involves risk — never wager more than you can afford to lose.

If you or someone you know has a gambling problem, call 1-800-MY-RESET (National Problem Gambling Helpline) or visit ncpgambling.org. Must be 21+ in most jurisdictions. Please gamble responsibly.

© 2026 LineTerminal. All rights reserved.