Milwaukee Brewers Lead St. Louis Cardinals 7-6 in Head-to-Head Matchups (2025)

MLB5-8-0 ATS (38.46%)

The Milwaukee Brewers are 7-6 against the St. Louis Cardinals in 2025 in head-to-head matchups, going 5-8-0 ATS (38.46% cover rate) with -28.57% ROI. Games average 8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.

See methodology.

Brewers vs Cardinals Betting Record — 2025

Against the Spread
5-8-0
Win %
38.46%
ROI
-28.57%
Units
-3.7
Moneyline
7-6-0
Win %
53.85%
ROI
-7.72%
Units
-1.0
Over Rate
5-7-1
Win %
41.67%
ROI
-20.59%
Units
-2.5

From the Other Side — Cardinals vs Brewers

Against the Spread
8-5-0
Win %
61.54%
ROI
+0.92%
Units
+0.1
Moneyline
6-7-0
Win %
46.15%
ROI
-5.12%
Units
-0.7
Over Rate
5-7-1
Win %
41.67%
ROI
-20.59%
Units
-2.5

Venue Splits

Brewers Home
2-5-0 ATS
28.57% • -48.25%
5-2-0 ML (71.43%)
Cardinals Home
3-3-0 ATS
50% • -16.41%
4-2-0 ML (66.67%)

Scoring Averages

Brewers
4.2
PPG
3.8
allowed
Total
8
Avg
13
games
Cardinals
3.8
PPG
4.2
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/21L 5-1LU
09/20W 2-3WU
09/19L 7-1LO
09/14L 2-3LU
09/13W 9-8WO
09/12W 8-2WO
06/15W 3-2WU
06/14L 5-8LO
06/13W 3-2WU
06/12W 6-0WU
04/27W 1-7WP
04/26L 6-5LO
04/25L 3-2LU

Frequently Asked Questions

What is the Milwaukee Brewers vs St. Louis Cardinals 2025 record?
The Milwaukee Brewers are 7-6 against the St. Louis Cardinals in 2025 in head-to-head matchups.
What is the Milwaukee Brewers ATS record vs the St. Louis Cardinals?
The Milwaukee Brewers are 5-8-0 against the spread vs the St. Louis Cardinals in 2025 on DraftKings, with -28.57% ROI.
Do Milwaukee Brewers vs St. Louis Cardinals games go over or under?
Milwaukee Brewers vs St. Louis Cardinals games average 8 total points in 2025. The Over has hit 41.67% of the time.

More Brewers Matchups

Head-to-head betting record for Milwaukee Brewers vs St. Louis Cardinals in the 2025 season on LineTerminal. The Brewers are 7-6 straight up against the Cardinals and 5-8-0 against the spread (38.46% cover rate, -28.57% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

LineTerminal provides sports data and analytics for informational and entertainment purposes only. LineTerminal does not accept, place, or facilitate bets or wagers of any kind. Odds data is sourced from third-party providers and may not reflect exact lines at every sportsbook. Past performance does not guarantee future results. Sports betting involves risk — never wager more than you can afford to lose.

If you or someone you know has a gambling problem, call 1-800-MY-RESET (National Problem Gambling Helpline) or visit ncpgambling.org. Must be 21+ in most jurisdictions. Please gamble responsibly.

© 2026 LineTerminal LLC. All rights reserved.