Milwaukee Brewers Lead St. Louis Cardinals 43-40 in Head-to-Head Matchups

MLB38-33-0 ATS (53.52%)Data through 2025-09-21

Cardinals vs Brewers Betting Record

Against the Spread
38-33-0
Win %
53.52%
ROI
-6.73%
Units
-4.8
Moneyline
39-43-1
Win %
47.56%
ROI
-0.42%
Units
-0.3
Over Rate
29-40-2
Win %
42.03%
ROI
-19.88%
Units
-13.7

From the Other Side — Brewers vs Cardinals

Against the Spread
33-38-0
Win %
46.48%
ROI
-5.23%
Units
-3.7
Moneyline
43-39-1
Win %
52.44%
ROI
-4.41%
Units
-3.6
Over Rate
29-40-2
Win %
42.03%
ROI
-19.88%
Units
-13.7

Venue Splits

Cardinals Home
18-16-0 ATS
52.94% • -7.96%
19-20-0 ML (48.72%)
Brewers Home
17-20-0 ATS
45.95% • -4.31%
23-20-1 ML (53.49%)

Scoring Averages

Cardinals
3.8
PPG
4
allowed
Total
7.7
Avg
83
games
Brewers
4
PPG
3.8
allowed

Recent Matchups

DateScoreATSMLO/U
09/21W 5-1WU
09/20L 2-3LU
09/19W 7-1WO
09/14W 2-3WU
09/13L 9-8LO
09/12L 8-2LO
06/15L 3-2LU
06/14W 5-8WO
06/13L 3-2LU
06/12L 6-0LU
04/27L 1-7LP
04/26W 6-5WO
04/25W 3-2WU
09/04W 2-3WU
09/03W 4-7WO
09/02L 9-3LO
08/22W 3-0WU
08/21W 10-6WO
08/20L 2-3LU
05/12W 3-4WU

Frequently Asked Questions

What is the St. Louis Cardinals vs Milwaukee Brewers all-time record?
The St. Louis Cardinals are 40-43 against the Milwaukee Brewers in head-to-head matchups.
What is the St. Louis Cardinals ATS record vs the Milwaukee Brewers?
The St. Louis Cardinals are 38-33-0 against the spread vs the Milwaukee Brewers on DraftKings, with -6.73% ROI.
Do St. Louis Cardinals vs Milwaukee Brewers games go over or under?
St. Louis Cardinals vs Milwaukee Brewers games average 7.7 total points. The Over has hit 42.03% of the time.

More Cardinals Matchups

Head-to-head betting record for St. Louis Cardinals vs Milwaukee Brewers on LineTerminal. The Cardinals are 40-43 straight up against the Brewers and 38-33-0 against the spread (53.52% cover rate, -6.73% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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