St. Louis Cardinals Lead Chicago Cubs 4-2 in Head-to-Head Matchups (2026)

MLB2-4-0 ATS (33.33%)Updated 3 days ago

The Chicago Cubs are 2-4 against the St. Louis Cardinals in 2026 in head-to-head matchups, going 2-4-0 ATS (33.33% cover rate) with -19.5% ROI. Games average 9.2 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official MLB box scores.

See methodology.

Cubs vs Cardinals Betting Record — 2026

Against the Spread

2-4-0

Win %

33.33%

ROI

-19.5%

Units

-1.2

Moneyline

2-4-0

Win %

33.33%

ROI

-42.29%

Units

-2.5

Over Rate

3-3-0

Win %

50%

ROI

-6.19%

Units

-0.4

From the Other Side — Cardinals vs Cubs

Against the Spread

4-2-0

Win %

66.67%

ROI

+7.24%

Units

+0.4

Moneyline

4-2-0

Win %

66.67%

ROI

+42.06%

Units

+2.5

Over Rate

3-3-0

Win %

50%

ROI

-6.19%

Units

-0.4

Venue Splits

Cubs Home

1-2-0 ATS

33.33% • -15.33%

1-2-0 ML (33.33%)

Cardinals Home

2-1-0 ATS

66.67% • +6.29%

2-1-0 ML (66.67%)

Scoring Averages

Cubs

3.2

PPG

allowed

Total

9.2

Avg

games

Cardinals

PPG

3.2

allowed

Recent Matchups (2026)

Date	Matchup	Score	Spread	ATS	ML	O/U
07/052026-07-05	Cardinals @ Cubs	W 6-4	-1.5	✓	W	O
07/042026-07-04	Cardinals @ Cubs	L 0-3	-1.5	✗	L	U
07/032026-07-03	Cardinals @ Cubs	L 1-17	-1.5	✗	L	O
05/312026-05-31	Cubs @ Cardinals	L 5-1	-1.5	✗	L	U
05/302026-05-30	Cubs @ Cardinals	W 1-6	-1.5	✓	W	U
05/292026-05-29	Cubs @ Cardinals	L 6-5	-1.5	✗	L	O

Frequently Asked Questions

What is the Chicago Cubs vs St. Louis Cardinals 2026 record?

The Chicago Cubs are 2-4 against the St. Louis Cardinals in 2026 in head-to-head matchups.

What is the Chicago Cubs ATS record vs the St. Louis Cardinals?

The Chicago Cubs are 2-4-0 against the spread vs the St. Louis Cardinals in 2026 on DraftKings, with -19.5% ROI.

Do Chicago Cubs vs St. Louis Cardinals games go over or under?

Chicago Cubs vs St. Louis Cardinals games average 9.2 total points in 2026. The Over has hit 50% of the time.

More Cubs Matchups

vs Reds

vs Brewers

vs Pirates

See from Cardinals perspective

Head-to-head betting record for Chicago Cubs vs St. Louis Cardinals in the 2026 season on LineTerminal. The Cubs are 2-4 straight up against the Cardinals and 2-4-0 against the spread (33.33% cover rate, -19.5% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.