Clemson Tigers Lead Syracuse Orange 2-1 in Head-to-Head Matchups

NCAAF1-2-0 ATS (33.33%)Updated September 20, 2025

The Clemson Tigers are 2-1 against the Syracuse Orange in head-to-head matchups, going 1-2-0 ATS (33.33% cover rate) with -37.68% ROI. Games average 49.3 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Tigers vs Orange Betting Record

Against the Spread

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Moneyline

2-1-0

Win %

66.67%

ROI

-16.59%

Units

-0.5

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

From the Other Side — Orange vs Tigers

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.83%

Units

+0.8

Moneyline

1-2-0

Win %

33.33%

ROI

+125%

Units

+3.8

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Venue Splits

Tigers Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Orange Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Tigers

26.3

PPG

allowed

Total

49.3

Avg

games

Orange

PPG

26.3

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
09/202025-09-20	Orange @ Tigers	L 21-34	-17.5	✗	L	O
09/302023-09-30	Tigers @ Orange	W 14-31	-7	✓	W	U
10/222022-10-22	Orange @ Tigers	W 27-21	-14	✗	W	U

Frequently Asked Questions

What is the Clemson Tigers vs Syracuse Orange all-time record?

The Clemson Tigers are 2-1 against the Syracuse Orange in head-to-head matchups.

What is the Clemson Tigers ATS record vs the Syracuse Orange?

The Clemson Tigers are 1-2-0 against the spread vs the Syracuse Orange on DraftKings, with -37.68% ROI.

Do Clemson Tigers vs Syracuse Orange games go over or under?

Clemson Tigers vs Syracuse Orange games average 49.3 total points. The Over has hit 33.33% of the time.

More Tigers Matchups

See from Orange perspective

Head-to-head betting record for Clemson Tigers vs Syracuse Orange on LineTerminal. The Tigers are 2-1 straight up against the Orange and 1-2-0 against the spread (33.33% cover rate, -37.68% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.