Clemson Tigers Lead Syracuse Orange 2-1 in Head-to-Head Matchups

NCAAF2-1-0 ATS (66.67%)Updated September 20, 2025

The Syracuse Orange are 1-2 against the Clemson Tigers in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +27.83% ROI. Games average 49.3 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Orange vs Tigers Betting Record

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.83%

Units

+0.8

Moneyline

1-2-0

Win %

33.33%

ROI

+125%

Units

+3.8

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

From the Other Side — Tigers vs Orange

Against the Spread

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Moneyline

2-1-0

Win %

66.67%

ROI

-16.59%

Units

-0.5

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Venue Splits

Orange Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Tigers Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Scoring Averages

Orange

PPG

26.3

allowed

Total

49.3

Avg

games

Tigers

26.3

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
09/202025-09-20	Orange @ Tigers	W 21-34	-17.5	✓	W	O
09/302023-09-30	Tigers @ Orange	L 14-31	-7	✗	L	U
10/222022-10-22	Orange @ Tigers	L 27-21	-14	✓	L	U

Frequently Asked Questions

What is the Syracuse Orange vs Clemson Tigers all-time record?

The Syracuse Orange are 1-2 against the Clemson Tigers in head-to-head matchups.

What is the Syracuse Orange ATS record vs the Clemson Tigers?

The Syracuse Orange are 2-1-0 against the spread vs the Clemson Tigers on DraftKings, with +27.83% ROI.

Do Syracuse Orange vs Clemson Tigers games go over or under?

Syracuse Orange vs Clemson Tigers games average 49.3 total points. The Over has hit 33.33% of the time.

More Orange Matchups

See from Tigers perspective

Head-to-head betting record for Syracuse Orange vs Clemson Tigers on LineTerminal. The Orange are 1-2 straight up against the Tigers and 2-1-0 against the spread (66.67% cover rate, +27.83% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.