Clemson Tigers Lead Syracuse Orange 2-1 in Head-to-Head Matchups

NCAAF2-1-0 ATS (66.67%)Updated September 20, 2025

The Syracuse Orange are 1-2 against the Clemson Tigers in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +27.83% ROI. Games average 49.3 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Syracuse Orange vs Clemson Tigers Betting Record

Against the Spread

2-1-0

Win %

66.67%

ROI

+27.83%

Units

+0.8

Moneyline

1-2-0

Win %

33.33%

ROI

+125%

Units

+3.8

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

From the Other Side — Clemson Tigers vs Syracuse Orange

Against the Spread

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Moneyline

2-1-0

Win %

66.67%

ROI

-16.59%

Units

-0.5

Over Rate

1-2-0

Win %

33.33%

ROI

-37.68%

Units

-1.1

Venue Splits

Syracuse Orange Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Clemson Tigers Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Scoring Averages

Syracuse Orange

PPG

26.3

allowed

Total

49.3

Avg

games

Clemson Tigers

26.3

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
09/202025-09-20	Syracuse Orange @ Clemson Tigers	W 21-34	-17.5	✓	W	O
09/302023-09-30	Clemson Tigers @ Syracuse Orange	L 14-31	-7	✗	L	U
10/222022-10-22	Syracuse Orange @ Clemson Tigers	L 27-21	-14	✓	L	U

Frequently Asked Questions

What is the Syracuse Orange vs Clemson Tigers all-time record?

The Syracuse Orange are 1-2 against the Clemson Tigers in head-to-head matchups.

What is the Syracuse Orange ATS record vs the Clemson Tigers?

The Syracuse Orange are 2-1-0 against the spread vs the Clemson Tigers on DraftKings, with +27.83% ROI.

Do Syracuse Orange vs Clemson Tigers games go over or under?

Syracuse Orange vs Clemson Tigers games average 49.3 total points. The Over has hit 33.33% of the time.

More Syracuse Orange Matchups

vs Boston College Eagles

vs California Golden Bears

vs Duke Blue Devils

vs Florida State Seminoles

vs Georgia Tech Yellow Jackets

vs Louisville Cardinals

See from Clemson Tigers perspective

Head-to-head betting record for Syracuse Orange vs Clemson Tigers on LineTerminal. The Syracuse Orange are 1-2 straight up against the Clemson Tigers and 2-1-0 against the spread (66.67% cover rate, +27.83% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.