Louisville CardinalsAway34
Syracuse OrangeHome26SpreadCoverFav -14.5
MoneylineLoss
TotalOver56.5
NCAAF · Head to head
Syracuse Orange vs Louisville Cardinals
All recorded seasonsLast meeting Oct 17, 2026
Betting comparison
All seasons
Syracuse Orange
2 bets2-0-0Wins · Losses · Pushes
- Win rate
- 100%
- ROI
- +91.75%
- Units
- +1.84u
Louisville Cardinals
2 bets0-2-0Wins · Losses · Pushes
- Win rate
- 0%
- ROI
- -100%
- Units
- -2u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsSyracuse Orange28.5
Louisville Cardinals20.5
Combined49
Recent meetings
Bet results from the Syracuse Orange perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway34Syracuse OrangeHome26Louisville CardinalsAway7Syracuse OrangeHome31SpreadCoverFav -5.5
MoneylineWin
TotalUnder55.5
More Syracuse Orange matchups
About this matchup
What is the Syracuse Orange vs Louisville Cardinals all-time record?
The Syracuse Orange are 1-1 against the Louisville Cardinals in head-to-head matchups.
What is the Syracuse Orange ATS record vs the Louisville Cardinals?
The Syracuse Orange are 2-0-0 against the spread vs the Louisville Cardinals on DraftKings, with +91.75% ROI.
Do Syracuse Orange vs Louisville Cardinals games go over or under?
Syracuse Orange vs Louisville Cardinals games average 49 total points. The Over has hit 50% of the time.