Louisville CardinalsAway34
Syracuse OrangeHome26SpreadMissFav -14.5
MoneylineWin
TotalOver56.5
NCAAF · Head to head
Louisville Cardinals vs Syracuse Orange
All recorded seasonsLast meeting Oct 17, 2026
Betting comparison
All seasons
Louisville Cardinals
2 bets0-2-0Wins · Losses · Pushes
- Win rate
- 0%
- ROI
- -100%
- Units
- -2u
Syracuse Orange
2 bets2-0-0Wins · Losses · Pushes
- Win rate
- 100%
- ROI
- +91.75%
- Units
- +1.84u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals20.5
Syracuse Orange28.5
Combined49
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway34Syracuse OrangeHome26Louisville CardinalsAway7Syracuse OrangeHome31SpreadMissFav -5.5
MoneylineLoss
TotalUnder55.5
More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs Syracuse Orange all-time record?
The Louisville Cardinals are 1-1 against the Syracuse Orange in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the Syracuse Orange?
The Louisville Cardinals are 0-2-0 against the spread vs the Syracuse Orange on DraftKings, with -100% ROI.
Do Louisville Cardinals vs Syracuse Orange games go over or under?
Louisville Cardinals vs Syracuse Orange games average 49 total points. The Over has hit 50% of the time.