Clemson TigersAway20
Louisville CardinalsHome19SpreadMissFav -1.5
MoneylineLoss
TotalUnder50.5
NCAAF · Head to head
Louisville Cardinals vs Clemson Tigers
All recorded seasonsLast meeting Nov 14, 2025
Betting comparison
All seasons
Louisville Cardinals
3 bets1-2-0Wins · Losses · Pushes
- Win rate
- 33.33%
- ROI
- -36.36%
- Units
- -1.09u
Clemson Tigers
3 bets2-1-0Wins · Losses · Pushes
- Win rate
- 66.67%
- ROI
- +30.16%
- Units
- +0.9u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals22.7
Clemson Tigers24
Combined46.7
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
Clemson TigersAway20Louisville CardinalsHome19Louisville CardinalsAway33Clemson TigersHome21SpreadCoverFav -11
MoneylineWin
TotalUnder62.5
Louisville CardinalsAway16Clemson TigersHome31SpreadMissFav -7
MoneylineLoss
TotalUnder51.5
More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs Clemson Tigers all-time record?
The Louisville Cardinals are 1-2 against the Clemson Tigers in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the Clemson Tigers?
The Louisville Cardinals are 1-2-0 against the spread vs the Clemson Tigers on DraftKings, with -36.36% ROI.
Do Louisville Cardinals vs Clemson Tigers games go over or under?
Louisville Cardinals vs Clemson Tigers games average 46.7 total points. The Over has hit 0% of the time.