Clemson Tigers Lead Louisville Cardinals 2-1 in Head-to-Head Matchups

NCAAF2-1-0 ATS (66.67%)Updated November 14, 2025

The Clemson Tigers are 2-1 against the Louisville Cardinals in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +30.16% ROI. Games average 46.7 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Tigers vs Cardinals Betting Record

Against the Spread

2-1-0

Win %

66.67%

ROI

+30.16%

Units

+0.9

Moneyline

2-1-0

Win %

66.67%

ROI

+12.79%

Units

+0.4

Over Rate

0-3-0

Win %

ROI

-100%

Units

-3.0

From the Other Side — Cardinals vs Tigers

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.36%

Units

-1.1

Moneyline

1-2-0

Win %

33.33%

ROI

+40%

Units

+1.2

Over Rate

0-3-0

Win %

ROI

-100%

Units

-3.0

Venue Splits

Tigers Home

1-1-0 ATS

50% • -2.38%

1-1-0 ML (50%)

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Tigers

PPG

22.7

allowed

Total

46.7

Avg

games

Cardinals

22.7

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/142025-11-14	Tigers @ Cardinals	W 19-20	-1.5	✓	W	U
11/022024-11-02	Cardinals @ Tigers	L 21-33	-11	✗	L	U
11/122022-11-12	Cardinals @ Tigers	W 31-16	-7	✓	W	U

Frequently Asked Questions

What is the Clemson Tigers vs Louisville Cardinals all-time record?

The Clemson Tigers are 2-1 against the Louisville Cardinals in head-to-head matchups.

What is the Clemson Tigers ATS record vs the Louisville Cardinals?

The Clemson Tigers are 2-1-0 against the spread vs the Louisville Cardinals on DraftKings, with +30.16% ROI.

Do Clemson Tigers vs Louisville Cardinals games go over or under?

Clemson Tigers vs Louisville Cardinals games average 46.7 total points. The Over has hit 0% of the time.

More Tigers Matchups

See from Cardinals perspective

Head-to-head betting record for Clemson Tigers vs Louisville Cardinals on LineTerminal. The Tigers are 2-1 straight up against the Cardinals and 2-1-0 against the spread (66.67% cover rate, +30.16% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.