Clemson TigersAway20
Louisville CardinalsHome19SpreadCoverFav -1.5
MoneylineWin
TotalUnder50.5
NCAAF · Head to head
Clemson Tigers vs Louisville Cardinals
All recorded seasonsLast meeting Nov 14, 2025
Betting comparison
All seasons
Clemson Tigers
3 bets2-1-0Wins · Losses · Pushes
- Win rate
- 66.67%
- ROI
- +30.16%
- Units
- +0.9u
Louisville Cardinals
3 bets1-2-0Wins · Losses · Pushes
- Win rate
- 33.33%
- ROI
- -36.36%
- Units
- -1.09u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsClemson Tigers24
Louisville Cardinals22.7
Combined46.7
Recent meetings
Bet results from the Clemson Tigers perspective. Spread values show the favorite’s closing line.
Clemson TigersAway20Louisville CardinalsHome19Louisville CardinalsAway33Clemson TigersHome21SpreadMissFav -11
MoneylineLoss
TotalUnder62.5
Louisville CardinalsAway16Clemson TigersHome31SpreadCoverFav -7
MoneylineWin
TotalUnder51.5
More Clemson Tigers matchups
About this matchup
What is the Clemson Tigers vs Louisville Cardinals all-time record?
The Clemson Tigers are 2-1 against the Louisville Cardinals in head-to-head matchups.
What is the Clemson Tigers ATS record vs the Louisville Cardinals?
The Clemson Tigers are 2-1-0 against the spread vs the Louisville Cardinals on DraftKings, with +30.16% ROI.
Do Clemson Tigers vs Louisville Cardinals games go over or under?
Clemson Tigers vs Louisville Cardinals games average 46.7 total points. The Over has hit 0% of the time.