Clemson Tigers Lead Florida State Seminoles 3-1 in Head-to-Head Matchups

NCAAF2-2-0 ATS (50%)Updated November 8, 2025

The Clemson Tigers are 3-1 against the Florida State Seminoles in head-to-head matchups, going 2-2-0 ATS (50% cover rate) with -4.95% ROI. Games average 48.3 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Tigers vs Seminoles Betting Record

Against the Spread

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

Moneyline

3-1-0

Win %

75%

ROI

+12.02%

Units

+0.5

Over Rate

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

From the Other Side — Seminoles vs Tigers

Against the Spread

2-2-0

Win %

50%

ROI

-4.55%

Units

-0.2

Moneyline

1-3-0

Win %

25%

ROI

-55.77%

Units

-2.2

Over Rate

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

Venue Splits

Tigers Home

1-1-0 ATS

50% • -5.36%

1-1-0 ML (50%)

Seminoles Home

1-1-0 ATS

50% • -4.55%

0-2-0 ML (0%)

Scoring Averages

Tigers

27.8

PPG

20.5

allowed

Total

48.3

Avg

games

Seminoles

20.5

PPG

27.8

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/082025-11-08	Seminoles @ Tigers	W 24-10	-1.5	✓	W	U
10/052024-10-05	Tigers @ Seminoles	W 13-29	-16.5	✗	W	U
09/232023-09-23	Seminoles @ Tigers	L 24-31	-2	✗	L	U
10/152022-10-15	Tigers @ Seminoles	W 28-34	-4.5	✓	W	O

Frequently Asked Questions

What is the Clemson Tigers vs Florida State Seminoles all-time record?

The Clemson Tigers are 3-1 against the Florida State Seminoles in head-to-head matchups.

What is the Clemson Tigers ATS record vs the Florida State Seminoles?

The Clemson Tigers are 2-2-0 against the spread vs the Florida State Seminoles on DraftKings, with -4.95% ROI.

Do Clemson Tigers vs Florida State Seminoles games go over or under?

Clemson Tigers vs Florida State Seminoles games average 48.3 total points. The Over has hit 25% of the time.

More Tigers Matchups

See from Seminoles perspective

Head-to-head betting record for Clemson Tigers vs Florida State Seminoles on LineTerminal. The Tigers are 3-1 straight up against the Seminoles and 2-2-0 against the spread (50% cover rate, -4.95% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.