Clemson Tigers Lead Florida State Seminoles 3-1 in Head-to-Head Matchups

NCAAF2-2-0 ATS (50%)Updated November 8, 2025

The Florida State Seminoles are 1-3 against the Clemson Tigers in head-to-head matchups, going 2-2-0 ATS (50% cover rate) with -4.55% ROI. Games average 48.3 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Seminoles vs Tigers Betting Record

Against the Spread

2-2-0

Win %

50%

ROI

-4.55%

Units

-0.2

Moneyline

1-3-0

Win %

25%

ROI

-55.77%

Units

-2.2

Over Rate

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

From the Other Side — Tigers vs Seminoles

Against the Spread

2-2-0

Win %

50%

ROI

-4.95%

Units

-0.2

Moneyline

3-1-0

Win %

75%

ROI

+12.02%

Units

+0.5

Over Rate

1-3-0

Win %

25%

ROI

-52.27%

Units

-2.1

Venue Splits

Seminoles Home

1-1-0 ATS

50% • -4.55%

0-2-0 ML (0%)

Tigers Home

1-1-0 ATS

50% • -5.36%

1-1-0 ML (50%)

Scoring Averages

Seminoles

20.5

PPG

27.8

allowed

Total

48.3

Avg

games

Tigers

27.8

PPG

20.5

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/082025-11-08	Seminoles @ Tigers	L 24-10	-1.5	✗	L	U
10/052024-10-05	Tigers @ Seminoles	L 13-29	-16.5	✓	L	U
09/232023-09-23	Seminoles @ Tigers	W 24-31	-2	✓	W	U
10/152022-10-15	Tigers @ Seminoles	L 28-34	-4.5	✗	L	O

Frequently Asked Questions

What is the Florida State Seminoles vs Clemson Tigers all-time record?

The Florida State Seminoles are 1-3 against the Clemson Tigers in head-to-head matchups.

What is the Florida State Seminoles ATS record vs the Clemson Tigers?

The Florida State Seminoles are 2-2-0 against the spread vs the Clemson Tigers on DraftKings, with -4.55% ROI.

Do Florida State Seminoles vs Clemson Tigers games go over or under?

Florida State Seminoles vs Clemson Tigers games average 48.3 total points. The Over has hit 25% of the time.

More Seminoles Matchups

See from Tigers perspective

Head-to-head betting record for Florida State Seminoles vs Clemson Tigers on LineTerminal. The Seminoles are 1-3 straight up against the Tigers and 2-2-0 against the spread (50% cover rate, -4.55% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.