Arizona Cardinals Lead San Francisco 49ers 2-0 in Head-to-Head Matchups (2024-25)

NFL0-2-0 ATS (0%)Updated January 5, 2025

The San Francisco 49ers are 0-2 against the Arizona Cardinals in 2024-25 in head-to-head matchups, going 0-2-0 ATS (0% cover rate) with -100% ROI. Games average 59 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

49ers vs Cardinals Betting Record — 2024-25

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-0.98%

Units

-0.0

From the Other Side — Cardinals vs 49ers

Against the Spread

2-0-0

Win %

100%

ROI

+87.02%

Units

+1.7

Moneyline

2-0-0

Win %

100%

ROI

+162.94%

Units

+3.3

Over Rate

1-1-0

Win %

50%

ROI

-0.98%

Units

-0.0

Venue Splits

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Cardinals Home

1-0-0 ATS

100% • +89.29%

1-0-0 ML (100%)

Scoring Averages

49ers

23.5

PPG

35.5

allowed

Total

Avg

games

Cardinals

35.5

PPG

23.5

allowed

Recent Matchups (2024-25)

Date	Matchup	Score	Spread	ATS	ML	O/U
01/052025-01-05	49ers @ Cardinals	L 47-24	-4.5	✗	L	O
10/062024-10-06	Cardinals @ 49ers	L 23-24	-7.5	✗	L	U

Frequently Asked Questions

What is the San Francisco 49ers vs Arizona Cardinals 2024-25 record?

The San Francisco 49ers are 0-2 against the Arizona Cardinals in 2024-25 in head-to-head matchups.

What is the San Francisco 49ers ATS record vs the Arizona Cardinals?

The San Francisco 49ers are 0-2-0 against the spread vs the Arizona Cardinals in 2024-25 on DraftKings, with -100% ROI.

Do San Francisco 49ers vs Arizona Cardinals games go over or under?

San Francisco 49ers vs Arizona Cardinals games average 59 total points in 2024-25. The Over has hit 50% of the time.

More 49ers Matchups

vs Rams

vs Seahawks

See from Cardinals perspective

Head-to-head betting record for San Francisco 49ers vs Arizona Cardinals in the 2024-25 season on LineTerminal. The 49ers are 0-2 straight up against the Cardinals and 0-2-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.