San Francisco 49ers 2025-26 Schedule
2025-26 · 13-6 overall · 12-7 ATS · 19 games
The San Francisco 49ers are 13-6 in 2025-26 across 19 games, going 12-7 against the spread (63% cover rate). Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.
| Date | Opponent | Score | ATS | ML | O/U |
|---|---|---|---|---|---|
| 2026-01-17 |  @ Seahawks | L 41-6 | ✗ | L | O |
| 2026-01-11 |  @ Eagles | W 19-23 | ✓ | W | U |
| 2026-01-03 | vs Seahawks | L 3-13 | ✗ | L | U |
| 2025-12-28 |  vs Bears | W 42-38 | ✓ | W | O |
| 2025-12-22 |  @ Colts | W 27-48 | ✓ | W | O |
| 2025-12-14 |  vs Titans | W 37-24 | ✓ | W | O |
| 2025-11-30 |  @ Browns | W 8-26 | ✓ | W | U |
| 2025-11-24 |  vs Panthers | W 20-9 | ✓ | W | U |
| 2025-11-16 |  @ Cardinals | W 22-41 | ✓ | W | O |
| 2025-11-09 |  vs Rams | L 26-42 | ✗ | L | O |
| 2025-11-02 |  @ Giants | W 24-34 | ✓ | W | O |
| 2025-10-26 |  @ Texans | L 26-15 | ✗ | L | U |
| 2025-10-19 |  vs Falcons | W 20-10 | ✓ | W | U |
| 2025-10-12 |  @ Buccaneers | L 30-19 | ✗ | L | O |
| 2025-10-02 | @ Rams | W 23-26 | ✓ | W | O |
| 2025-09-28 |  vs Jaguars | L 21-26 | ✗ | L | O |
| 2025-09-21 | vs Cardinals | W 16-15 | ✗ | W | U |
| 2025-09-14 |  @ Saints | W 21-26 | ✓ | W | O |
| 2025-09-07 | @ Seahawks | W 13-17 | ✓ | W | U |