Los Angeles Rams Lead San Francisco 49ers 2-0 in Head-to-Head Matchups (2024-25)

NFL2-0-0 ATS (100%)Updated December 12, 2024

The Los Angeles Rams are 2-0 against the San Francisco 49ers in 2024-25 in head-to-head matchups, going 2-0-0 ATS (100% cover rate) with +87.02% ROI. Games average 34.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NFL box scores.

See methodology.

Rams vs 49ers Betting Record — 2024-25

Against the Spread

2-0-0

Win %

100%

ROI

+87.02%

Units

+1.7

Moneyline

2-0-0

Win %

100%

ROI

+170%

Units

+3.4

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

From the Other Side — 49ers vs Rams

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-3.7%

Units

-0.1

Venue Splits

Rams Home

1-0-0 ATS

100% • +89.29%

1-0-0 ML (100%)

49ers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Rams

19.5

PPG

allowed

Total

34.5

Avg

games

49ers

PPG

19.5

allowed

Recent Matchups (2024-25)

Date	Matchup	Score	Spread	ATS	ML	O/U
12/122024-12-12	Rams @ 49ers	W 6-12	-3	✓	W	U
09/222024-09-22	49ers @ Rams	W 27-24	-6	✓	W	O

Frequently Asked Questions

What is the Los Angeles Rams vs San Francisco 49ers 2024-25 record?

The Los Angeles Rams are 2-0 against the San Francisco 49ers in 2024-25 in head-to-head matchups.

What is the Los Angeles Rams ATS record vs the San Francisco 49ers?

The Los Angeles Rams are 2-0-0 against the spread vs the San Francisco 49ers in 2024-25 on DraftKings, with +87.02% ROI.

Do Los Angeles Rams vs San Francisco 49ers games go over or under?

Los Angeles Rams vs San Francisco 49ers games average 34.5 total points in 2024-25. The Over has hit 50% of the time.

More Rams Matchups

vs Cardinals

vs Seahawks

See from 49ers perspective

Head-to-head betting record for Los Angeles Rams vs San Francisco 49ers in the 2024-25 season on LineTerminal. The Rams are 2-0 straight up against the 49ers and 2-0-0 against the spread (100% cover rate, +87.02% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.