SMU Mustangs Lead Louisville Cardinals 1-0 in Head-to-Head Matchups (2025-26)

NCAAF0-1-0 ATS (0%)Updated November 22, 2025

The Louisville Cardinals are 0-1 against the SMU Mustangs in 2025-26 in head-to-head matchups, going 0-1-0 ATS (0% cover rate) with -100% ROI. Games average 44 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Mustangs Betting Record — 2025-26

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

From the Other Side — Mustangs vs Cardinals

Against the Spread

1-0-0

Win %

100%

ROI

+92.59%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+54.05%

Units

+0.5

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

Venue Splits

Cardinals Home

Mustangs Home

1-0-0 ATS

100% • +92.59%

1-0-0 ML (100%)

Scoring Averages

Cardinals

PPG

allowed

Total

Avg

games

Mustangs

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/222025-11-22	Cardinals @ Mustangs	L 38-6	-4	✗	L	U

Frequently Asked Questions

What is the Louisville Cardinals vs SMU Mustangs 2025-26 record?

The Louisville Cardinals are 0-1 against the SMU Mustangs in 2025-26 in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the SMU Mustangs?

The Louisville Cardinals are 0-1-0 against the spread vs the SMU Mustangs in 2025-26 on DraftKings, with -100% ROI.

Do Louisville Cardinals vs SMU Mustangs games go over or under?

Louisville Cardinals vs SMU Mustangs games average 44 total points in 2025-26. The Over has hit 0% of the time.

More Cardinals Matchups

See from Mustangs perspective

Head-to-head betting record for Louisville Cardinals vs SMU Mustangs in the 2025-26 season on LineTerminal. The Cardinals are 0-1 straight up against the Mustangs and 0-1-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.