Louisville CardinalsAway6
SMU MustangsHome38SpreadMissFav -4
MoneylineLoss
TotalUnder49.5
NCAAF · Head to head
Louisville Cardinals vs SMU Mustangs
2025-26 seasonLast meeting Nov 22, 2025
Betting comparison
2025-26
Louisville Cardinals
1 bets0-1-0Wins · Losses · Pushes
- Win rate
- 0%
- ROI
- -100%
- Units
- -1u
SMU Mustangs
1 bets1-0-0Wins · Losses · Pushes
- Win rate
- 100%
- ROI
- +92.59%
- Units
- +0.93u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals6
SMU Mustangs38
Combined44
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway6SMU MustangsHome38More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs SMU Mustangs 2025-26 record?
The Louisville Cardinals are 0-1 against the SMU Mustangs in 2025-26 in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the SMU Mustangs?
The Louisville Cardinals are 0-1-0 against the spread vs the SMU Mustangs in 2025-26 on DraftKings, with -100% ROI.
Do Louisville Cardinals vs SMU Mustangs games go over or under?
Louisville Cardinals vs SMU Mustangs games average 44 total points in 2025-26. The Over has hit 0% of the time.