SMU Mustangs Lead Louisville Cardinals 1-0 in Head-to-Head Matchups (2025-26)

NCAAF1-0-0 ATS (100%)Updated November 22, 2025

The SMU Mustangs are 1-0 against the Louisville Cardinals in 2025-26 in head-to-head matchups, going 1-0-0 ATS (100% cover rate) with +92.59% ROI. Games average 44 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Mustangs vs Cardinals Betting Record — 2025-26

Against the Spread

1-0-0

Win %

100%

ROI

+92.59%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+54.05%

Units

+0.5

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

From the Other Side — Cardinals vs Mustangs

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

Venue Splits

Mustangs Home

1-0-0 ATS

100% • +92.59%

1-0-0 ML (100%)

Cardinals Home

Scoring Averages

Mustangs

PPG

allowed

Total

Avg

games

Cardinals

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/222025-11-22	Cardinals @ Mustangs	W 38-6	-4	✓	W	U

Frequently Asked Questions

What is the SMU Mustangs vs Louisville Cardinals 2025-26 record?

The SMU Mustangs are 1-0 against the Louisville Cardinals in 2025-26 in head-to-head matchups.

What is the SMU Mustangs ATS record vs the Louisville Cardinals?

The SMU Mustangs are 1-0-0 against the spread vs the Louisville Cardinals in 2025-26 on DraftKings, with +92.59% ROI.

Do SMU Mustangs vs Louisville Cardinals games go over or under?

SMU Mustangs vs Louisville Cardinals games average 44 total points in 2025-26. The Over has hit 0% of the time.

More Mustangs Matchups

See from Cardinals perspective

Head-to-head betting record for SMU Mustangs vs Louisville Cardinals in the 2025-26 season on LineTerminal. The Mustangs are 1-0 straight up against the Cardinals and 1-0-0 against the spread (100% cover rate, +92.59% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.