SMU MustangsAway31
Louisville CardinalsHome41SpreadMissFav -3
MoneylineLoss
TotalOver57.5
NCAAF · Head to head
SMU Mustangs vs Louisville Cardinals
All recorded seasonsLast meeting Sep 19, 2026
Betting comparison
All seasons
SMU Mustangs
3 bets2-1-0Wins · Losses · Pushes
- Win rate
- 66.67%
- ROI
- +28.4%
- Units
- +0.85u
Louisville Cardinals
3 bets1-2-0Wins · Losses · Pushes
- Win rate
- 33.33%
- ROI
- -35.8%
- Units
- -1.07u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsSMU Mustangs34.3
Louisville Cardinals24.7
Combined59
Recent meetings
Bet results from the SMU Mustangs perspective. Spread values show the favorite’s closing line.
SMU MustangsAway31Louisville CardinalsHome41Louisville CardinalsAway6SMU MustangsHome38SpreadCoverFav -4
MoneylineWin
TotalUnder49.5
SMU MustangsAway34Louisville CardinalsHome27SpreadCoverFav -6.5
MoneylineWin
TotalOver55
More SMU Mustangs matchups
About this matchup
What is the SMU Mustangs vs Louisville Cardinals all-time record?
The SMU Mustangs are 2-1 against the Louisville Cardinals in head-to-head matchups.
What is the SMU Mustangs ATS record vs the Louisville Cardinals?
The SMU Mustangs are 2-1-0 against the spread vs the Louisville Cardinals on DraftKings, with +28.4% ROI.
Do SMU Mustangs vs Louisville Cardinals games go over or under?
SMU Mustangs vs Louisville Cardinals games average 59 total points. The Over has hit 66.67% of the time.