SMU Mustangs Lead Louisville Cardinals 2-0 in Head-to-Head Matchups

NCAAF2-0-0 ATS (100%)Updated November 22, 2025

The SMU Mustangs are 2-0 against the Louisville Cardinals in head-to-head matchups, going 2-0-0 ATS (100% cover rate) with +92.59% ROI. Games average 52.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Mustangs vs Cardinals Betting Record

Against the Spread

2-0-0

Win %

100%

ROI

+92.59%

Units

+1.9

Moneyline

2-0-0

Win %

100%

ROI

+134.53%

Units

+2.7

Over Rate

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

From the Other Side — Cardinals vs Mustangs

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

Venue Splits

Mustangs Home

1-0-0 ATS

100% • +92.59%

1-0-0 ML (100%)

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Mustangs

PPG

16.5

allowed

Total

52.5

Avg

games

Cardinals

16.5

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/222025-11-22	Cardinals @ Mustangs	W 38-6	-4	✓	W	U
10/052024-10-05	Mustangs @ Cardinals	W 27-34	-6.5	✓	W	O

Frequently Asked Questions

What is the SMU Mustangs vs Louisville Cardinals all-time record?

The SMU Mustangs are 2-0 against the Louisville Cardinals in head-to-head matchups.

What is the SMU Mustangs ATS record vs the Louisville Cardinals?

The SMU Mustangs are 2-0-0 against the spread vs the Louisville Cardinals on DraftKings, with +92.59% ROI.

Do SMU Mustangs vs Louisville Cardinals games go over or under?

SMU Mustangs vs Louisville Cardinals games average 52.5 total points. The Over has hit 50% of the time.

More Mustangs Matchups

See from Cardinals perspective

Head-to-head betting record for SMU Mustangs vs Louisville Cardinals on LineTerminal. The Mustangs are 2-0 straight up against the Cardinals and 2-0-0 against the spread (100% cover rate, +92.59% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.