SMU Mustangs Lead Louisville Cardinals 2-0 in Head-to-Head Matchups

NCAAF0-2-0 ATS (0%)Updated November 22, 2025

The Louisville Cardinals are 0-2 against the SMU Mustangs in head-to-head matchups, going 0-2-0 ATS (0% cover rate) with -100% ROI. Games average 52.5 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Mustangs Betting Record

Against the Spread

0-2-0

Win %

ROI

-100%

Units

-2.0

Moneyline

0-2-0

Win %

ROI

-100%

Units

-2.0

Over Rate

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

From the Other Side — Mustangs vs Cardinals

Against the Spread

2-0-0

Win %

100%

ROI

+92.59%

Units

+1.9

Moneyline

2-0-0

Win %

100%

ROI

+134.53%

Units

+2.7

Over Rate

1-1-0

Win %

50%

ROI

-5.36%

Units

-0.1

Venue Splits

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Mustangs Home

1-0-0 ATS

100% • +92.59%

1-0-0 ML (100%)

Scoring Averages

Cardinals

16.5

PPG

allowed

Total

52.5

Avg

games

Mustangs

PPG

16.5

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/222025-11-22	Cardinals @ Mustangs	L 38-6	-4	✗	L	U
10/052024-10-05	Mustangs @ Cardinals	L 27-34	-6.5	✗	L	O

Frequently Asked Questions

What is the Louisville Cardinals vs SMU Mustangs all-time record?

The Louisville Cardinals are 0-2 against the SMU Mustangs in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the SMU Mustangs?

The Louisville Cardinals are 0-2-0 against the spread vs the SMU Mustangs on DraftKings, with -100% ROI.

Do Louisville Cardinals vs SMU Mustangs games go over or under?

Louisville Cardinals vs SMU Mustangs games average 52.5 total points. The Over has hit 50% of the time.

More Cardinals Matchups

See from Mustangs perspective

Head-to-head betting record for Louisville Cardinals vs SMU Mustangs on LineTerminal. The Cardinals are 0-2 straight up against the Mustangs and 0-2-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.