SMU MustangsAway31
Louisville CardinalsHome41SpreadCoverFav -3
MoneylineWin
TotalOver57.5
NCAAF · Head to head
Louisville Cardinals vs SMU Mustangs
All recorded seasonsLast meeting Sep 19, 2026
Betting comparison
All seasons
Louisville Cardinals
3 bets1-2-0Wins · Losses · Pushes
- Win rate
- 33.33%
- ROI
- -35.8%
- Units
- -1.07u
SMU Mustangs
3 bets2-1-0Wins · Losses · Pushes
- Win rate
- 66.67%
- ROI
- +28.4%
- Units
- +0.85u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals24.7
SMU Mustangs34.3
Combined59
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
SMU MustangsAway31Louisville CardinalsHome41Louisville CardinalsAway6SMU MustangsHome38SpreadMissFav -4
MoneylineLoss
TotalUnder49.5
SMU MustangsAway34Louisville CardinalsHome27SpreadMissFav -6.5
MoneylineLoss
TotalOver55
More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs SMU Mustangs all-time record?
The Louisville Cardinals are 1-2 against the SMU Mustangs in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the SMU Mustangs?
The Louisville Cardinals are 1-2-0 against the spread vs the SMU Mustangs on DraftKings, with -35.8% ROI.
Do Louisville Cardinals vs SMU Mustangs games go over or under?
Louisville Cardinals vs SMU Mustangs games average 59 total points. The Over has hit 66.67% of the time.