Clemson Tigers Lead Louisville Cardinals 1-0 in Head-to-Head Matchups (2025-26)

NCAAF0-1-0 ATS (0%)Updated November 14, 2025

The Louisville Cardinals are 0-1 against the Clemson Tigers in 2025-26 in head-to-head matchups, going 0-1-0 ATS (0% cover rate) with -100% ROI. Games average 39 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Tigers Betting Record — 2025-26

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

From the Other Side — Tigers vs Cardinals

Against the Spread

1-0-0

Win %

100%

ROI

+95.24%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+102%

Units

+1.0

Over Rate

0-1-0

Win %

ROI

-100%

Units

-1.0

Venue Splits

Cardinals Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Tigers Home

Scoring Averages

Cardinals

PPG

allowed

Total

Avg

games

Tigers

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
11/142025-11-14	Tigers @ Cardinals	L 19-20	-1.5	✗	L	U

Frequently Asked Questions

What is the Louisville Cardinals vs Clemson Tigers 2025-26 record?

The Louisville Cardinals are 0-1 against the Clemson Tigers in 2025-26 in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the Clemson Tigers?

The Louisville Cardinals are 0-1-0 against the spread vs the Clemson Tigers in 2025-26 on DraftKings, with -100% ROI.

Do Louisville Cardinals vs Clemson Tigers games go over or under?

Louisville Cardinals vs Clemson Tigers games average 39 total points in 2025-26. The Over has hit 0% of the time.

More Cardinals Matchups

See from Tigers perspective

Head-to-head betting record for Louisville Cardinals vs Clemson Tigers in the 2025-26 season on LineTerminal. The Cardinals are 0-1 straight up against the Tigers and 0-1-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.