Louisville Cardinals Lead Pittsburgh Panthers 1-0 in Head-to-Head Matchups (2025-26)

NCAAF1-0-0 ATS (100%)Updated September 27, 2025

The Louisville Cardinals are 1-0 against the Pittsburgh Panthers in 2025-26 in head-to-head matchups, going 1-0-0 ATS (100% cover rate) with +92.59% ROI. Games average 61 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cardinals vs Panthers Betting Record — 2025-26

Against the Spread

1-0-0

Win %

100%

ROI

+92.59%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+64.52%

Units

+0.7

Over Rate

1-0-0

Win %

100%

ROI

+86.96%

Units

+0.9

From the Other Side — Panthers vs Cardinals

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

1-0-0

Win %

100%

ROI

+86.96%

Units

+0.9

Venue Splits

Cardinals Home

Panthers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Scoring Averages

Cardinals

PPG

allowed

Total

Avg

games

Panthers

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
09/272025-09-27	Cardinals @ Panthers	W 27-34	-3	✓	W	O

Frequently Asked Questions

What is the Louisville Cardinals vs Pittsburgh Panthers 2025-26 record?

The Louisville Cardinals are 1-0 against the Pittsburgh Panthers in 2025-26 in head-to-head matchups.

What is the Louisville Cardinals ATS record vs the Pittsburgh Panthers?

The Louisville Cardinals are 1-0-0 against the spread vs the Pittsburgh Panthers in 2025-26 on DraftKings, with +92.59% ROI.

Do Louisville Cardinals vs Pittsburgh Panthers games go over or under?

Louisville Cardinals vs Pittsburgh Panthers games average 61 total points in 2025-26. The Over has hit 100% of the time.

More Cardinals Matchups

See from Panthers perspective

Head-to-head betting record for Louisville Cardinals vs Pittsburgh Panthers in the 2025-26 season on LineTerminal. The Cardinals are 1-0 straight up against the Panthers and 1-0-0 against the spread (100% cover rate, +92.59% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.