Louisville CardinalsAway34
Pittsburgh PanthersHome27SpreadCoverFav -3
MoneylineWin
TotalOver53.5
NCAAF · Head to head
Louisville Cardinals vs Pittsburgh Panthers
All recorded seasonsLast meeting Sep 27, 2025
Betting comparison
All seasons
Louisville Cardinals
4 bets3-1-0Wins · Losses · Pushes
- Win rate
- 75%
- ROI
- +42.61%
- Units
- +1.7u
Pittsburgh Panthers
4 bets1-3-0Wins · Losses · Pushes
- Win rate
- 25%
- ROI
- -51.19%
- Units
- -2.05u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsLouisville Cardinals29
Pittsburgh Panthers21
Combined50
Recent meetings
Bet results from the Louisville Cardinals perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway34Pittsburgh PanthersHome27Pittsburgh PanthersAway9Louisville CardinalsHome37SpreadCoverFav -7
MoneylineWin
TotalUnder57
Louisville CardinalsAway21Pittsburgh PanthersHome38SpreadMissFav -7
MoneylineLoss
TotalOver45
Pittsburgh PanthersAway10Louisville CardinalsHome24SpreadCoverFav -1.5
MoneylineWin
TotalUnder55
More Louisville Cardinals matchups
About this matchup
What is the Louisville Cardinals vs Pittsburgh Panthers all-time record?
The Louisville Cardinals are 3-1 against the Pittsburgh Panthers in head-to-head matchups.
What is the Louisville Cardinals ATS record vs the Pittsburgh Panthers?
The Louisville Cardinals are 3-1-0 against the spread vs the Pittsburgh Panthers on DraftKings, with +42.61% ROI.
Do Louisville Cardinals vs Pittsburgh Panthers games go over or under?
Louisville Cardinals vs Pittsburgh Panthers games average 50 total points. The Over has hit 50% of the time.