Louisville Cardinals Lead Pittsburgh Panthers 3-1 in Head-to-Head Matchups

NCAAF1-3-0 ATS (25%)Updated September 27, 2025

The Pittsburgh Panthers are 1-3 against the Louisville Cardinals in head-to-head matchups, going 1-3-0 ATS (25% cover rate) with -51.19% ROI. Games average 50 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Panthers vs Cardinals Betting Record

Against the Spread

1-3-0

Win %

25%

ROI

-51.19%

Units

-2.0

Moneyline

1-3-0

Win %

25%

ROI

-16.25%

Units

-0.7

Over Rate

2-2-0

Win %

50%

ROI

-5.53%

Units

-0.2

From the Other Side — Cardinals vs Panthers

Against the Spread

3-1-0

Win %

75%

ROI

+42.61%

Units

+1.7

Moneyline

3-1-0

Win %

75%

ROI

+20.96%

Units

+0.8

Over Rate

2-2-0

Win %

50%

ROI

-5.53%

Units

-0.2

Venue Splits

Panthers Home

1-1-0 ATS

50% • -2.38%

1-1-0 ML (50%)

Cardinals Home

2-0-0 ATS

100% • +88.93%

2-0-0 ML (100%)

Scoring Averages

Panthers

PPG

allowed

Total

Avg

games

Cardinals

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
09/272025-09-27	Cardinals @ Panthers	L 27-34	-3	✗	L	O
11/232024-11-23	Panthers @ Cardinals	L 37-9	-7	✗	L	U
10/142023-10-14	Cardinals @ Panthers	W 38-21	-7	✓	W	O
10/222022-10-22	Panthers @ Cardinals	L 24-10	-1.5	✗	L	U

Frequently Asked Questions

What is the Pittsburgh Panthers vs Louisville Cardinals all-time record?

The Pittsburgh Panthers are 1-3 against the Louisville Cardinals in head-to-head matchups.

What is the Pittsburgh Panthers ATS record vs the Louisville Cardinals?

The Pittsburgh Panthers are 1-3-0 against the spread vs the Louisville Cardinals on DraftKings, with -51.19% ROI.

Do Pittsburgh Panthers vs Louisville Cardinals games go over or under?

Pittsburgh Panthers vs Louisville Cardinals games average 50 total points. The Over has hit 50% of the time.

More Panthers Matchups

See from Cardinals perspective

Head-to-head betting record for Pittsburgh Panthers vs Louisville Cardinals on LineTerminal. The Panthers are 1-3 straight up against the Cardinals and 1-3-0 against the spread (25% cover rate, -51.19% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.