Louisville CardinalsAway34
Pittsburgh PanthersHome27SpreadMissFav -3
MoneylineLoss
TotalOver53.5
NCAAF · Head to head
Pittsburgh Panthers vs Louisville Cardinals
All recorded seasonsLast meeting Sep 27, 2025
Betting comparison
All seasons
Pittsburgh Panthers
4 bets1-3-0Wins · Losses · Pushes
- Win rate
- 25%
- ROI
- -51.19%
- Units
- -2.05u
Louisville Cardinals
4 bets3-1-0Wins · Losses · Pushes
- Win rate
- 75%
- ROI
- +42.61%
- Units
- +1.7u
Closing lines · Flat 1u per bet · Methodology
Scoring per game
Average pointsPittsburgh Panthers21
Louisville Cardinals29
Combined50
Recent meetings
Bet results from the Pittsburgh Panthers perspective. Spread values show the favorite’s closing line.
Louisville CardinalsAway34Pittsburgh PanthersHome27Pittsburgh PanthersAway9Louisville CardinalsHome37SpreadMissFav -7
MoneylineLoss
TotalUnder57
Louisville CardinalsAway21Pittsburgh PanthersHome38SpreadCoverFav -7
MoneylineWin
TotalOver45
Pittsburgh PanthersAway10Louisville CardinalsHome24SpreadMissFav -1.5
MoneylineLoss
TotalUnder55
More Pittsburgh Panthers matchups
About this matchup
What is the Pittsburgh Panthers vs Louisville Cardinals all-time record?
The Pittsburgh Panthers are 1-3 against the Louisville Cardinals in head-to-head matchups.
What is the Pittsburgh Panthers ATS record vs the Louisville Cardinals?
The Pittsburgh Panthers are 1-3-0 against the spread vs the Louisville Cardinals on DraftKings, with -51.19% ROI.
Do Pittsburgh Panthers vs Louisville Cardinals games go over or under?
Pittsburgh Panthers vs Louisville Cardinals games average 50 total points. The Over has hit 50% of the time.