Louisville Cardinals Lead Pittsburgh Panthers 1-0 in Head-to-Head Matchups (2025-26)

NCAAF0-1-0 ATS (0%)Updated September 27, 2025

The Pittsburgh Panthers are 0-1 against the Louisville Cardinals in 2025-26 in head-to-head matchups, going 0-1-0 ATS (0% cover rate) with -100% ROI. Games average 61 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Panthers vs Cardinals Betting Record — 2025-26

Against the Spread

0-1-0

Win %

ROI

-100%

Units

-1.0

Moneyline

0-1-0

Win %

ROI

-100%

Units

-1.0

Over Rate

1-0-0

Win %

100%

ROI

+86.96%

Units

+0.9

From the Other Side — Cardinals vs Panthers

Against the Spread

1-0-0

Win %

100%

ROI

+92.59%

Units

+0.9

Moneyline

1-0-0

Win %

100%

ROI

+64.52%

Units

+0.7

Over Rate

1-0-0

Win %

100%

ROI

+86.96%

Units

+0.9

Venue Splits

Panthers Home

0-1-0 ATS

0% • -100%

0-1-0 ML (0%)

Cardinals Home

Scoring Averages

Panthers

PPG

allowed

Total

Avg

games

Cardinals

PPG

allowed

Recent Matchups (2025-26)

Date	Matchup	Score	Spread	ATS	ML	O/U
09/272025-09-27	Cardinals @ Panthers	L 27-34	-3	✗	L	O

Frequently Asked Questions

What is the Pittsburgh Panthers vs Louisville Cardinals 2025-26 record?

The Pittsburgh Panthers are 0-1 against the Louisville Cardinals in 2025-26 in head-to-head matchups.

What is the Pittsburgh Panthers ATS record vs the Louisville Cardinals?

The Pittsburgh Panthers are 0-1-0 against the spread vs the Louisville Cardinals in 2025-26 on DraftKings, with -100% ROI.

Do Pittsburgh Panthers vs Louisville Cardinals games go over or under?

Pittsburgh Panthers vs Louisville Cardinals games average 61 total points in 2025-26. The Over has hit 100% of the time.

More Panthers Matchups

See from Cardinals perspective

Head-to-head betting record for Pittsburgh Panthers vs Louisville Cardinals in the 2025-26 season on LineTerminal. The Panthers are 0-1 straight up against the Cardinals and 0-1-0 against the spread (0% cover rate, -100% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.