Cleveland Guardians Lead Minnesota Twins 9-4 in Head-to-Head Matchups (2025)

MLB7-6-0 ATS (53.85%)Data through 2025-09-21

Guardians vs Twins Betting Record — 2025

Against the Spread
7-6-0
Win %
53.85%
ROI
+5.9%
Units
+0.8
Moneyline
9-4-0
Win %
69.23%
ROI
+30.96%
Units
+4.0
Over Rate
4-8-1
Win %
33.33%
ROI
-34.71%
Units
-4.2

From the Other Side — Twins vs Guardians

Against the Spread
6-7-0
Win %
46.15%
ROI
-27.86%
Units
-3.6
Moneyline
4-9-0
Win %
30.77%
ROI
-37.73%
Units
-4.9
Over Rate
4-8-1
Win %
33.33%
ROI
-34.71%
Units
-4.2

Venue Splits

Guardians Home
2-5-0 ATS
28.57% • -55.17%
5-2-0 ML (71.43%)
Twins Home
1-5-0 ATS
16.67% • -72.37%
2-4-0 ML (33.33%)

Scoring Averages

Guardians
4.2
PPG
3.3
allowed
Total
7.5
Avg
13
games
Twins
3.3
PPG
4.2
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/21L 6-2LU
09/20W 0-8WU
09/20W 0-6WU
09/19W 2-6WP
08/03L 4-5LO
08/02W 5-4WO
08/01W 3-2WU
05/21W 1-5WU
05/19L 6-5LO
05/01W 4-3WU
04/30W 4-2WU
04/29W 2-1WU
04/28L 1-11LO

Frequently Asked Questions

What is the Cleveland Guardians vs Minnesota Twins all-time record?
The Cleveland Guardians are 9-4 against the Minnesota Twins in 2025 in head-to-head matchups.
What is the Cleveland Guardians ATS record vs the Minnesota Twins?
The Cleveland Guardians are 7-6-0 against the spread vs the Minnesota Twins in 2025 on DraftKings, with +5.9% ROI.
Do Cleveland Guardians vs Minnesota Twins games go over or under?
Cleveland Guardians vs Minnesota Twins games average 7.5 total points in 2025. The Over has hit 33.33% of the time.

More Guardians Matchups

Head-to-head betting record for Cleveland Guardians vs Minnesota Twins in the 2025 season on LineTerminal. The Guardians are 9-4 straight up against the Twins and 7-6-0 against the spread (53.85% cover rate, +5.9% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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