Cleveland Guardians Lead Minnesota Twins 9-4 in Head-to-Head Matchups (2025)

MLB6-7-0 ATS (46.15%)Data through 2025-09-21

Twins vs Guardians Betting Record — 2025

Against the Spread
6-7-0
Win %
46.15%
ROI
-27.86%
Units
-3.6
Moneyline
4-9-0
Win %
30.77%
ROI
-37.73%
Units
-4.9
Over Rate
4-8-1
Win %
33.33%
ROI
-34.71%
Units
-4.2

From the Other Side — Guardians vs Twins

Against the Spread
7-6-0
Win %
53.85%
ROI
+5.9%
Units
+0.8
Moneyline
9-4-0
Win %
69.23%
ROI
+30.96%
Units
+4.0
Over Rate
4-8-1
Win %
33.33%
ROI
-34.71%
Units
-4.2

Venue Splits

Twins Home
1-5-0 ATS
16.67% • -72.37%
2-4-0 ML (33.33%)
Guardians Home
2-5-0 ATS
28.57% • -55.17%
5-2-0 ML (71.43%)

Scoring Averages

Twins
3.3
PPG
4.2
allowed
Total
7.5
Avg
13
games
Guardians
4.2
PPG
3.3
allowed

Recent Matchups (2025)

DateScoreATSMLO/U
09/21W 6-2WU
09/20L 0-8LU
09/20L 0-6LU
09/19L 2-6LP
08/03W 4-5WO
08/02L 5-4LO
08/01L 3-2LU
05/21L 1-5LU
05/19W 6-5WO
05/01L 4-3LU
04/30L 4-2LU
04/29L 2-1LU
04/28W 1-11WO

Frequently Asked Questions

What is the Minnesota Twins vs Cleveland Guardians all-time record?
The Minnesota Twins are 4-9 against the Cleveland Guardians in 2025 in head-to-head matchups.
What is the Minnesota Twins ATS record vs the Cleveland Guardians?
The Minnesota Twins are 6-7-0 against the spread vs the Cleveland Guardians in 2025 on DraftKings, with -27.86% ROI.
Do Minnesota Twins vs Cleveland Guardians games go over or under?
Minnesota Twins vs Cleveland Guardians games average 7.5 total points in 2025. The Over has hit 33.33% of the time.

More Twins Matchups

Head-to-head betting record for Minnesota Twins vs Cleveland Guardians in the 2025 season on LineTerminal. The Twins are 4-9 straight up against the Guardians and 6-7-0 against the spread (46.15% cover rate, -27.86% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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