Cleveland Guardians Lead Minnesota Twins 38-19 in Head-to-Head Matchups

MLB26-31-0 ATS (45.61%)Data through 2025-09-21

Twins vs Guardians Betting Record

Against the Spread
26-31-0
Win %
45.61%
ROI
-13.23%
Units
-7.5
Moneyline
19-38-0
Win %
33.33%
ROI
-38.56%
Units
-22.0
Over Rate
19-36-2
Win %
34.55%
ROI
-33.26%
Units
-18.3

From the Other Side — Guardians vs Twins

Against the Spread
31-26-0
Win %
54.39%
ROI
-1.84%
Units
-1.1
Moneyline
38-19-0
Win %
66.67%
ROI
+30.58%
Units
+17.4
Over Rate
19-36-2
Win %
34.55%
ROI
-33.26%
Units
-18.3

Venue Splits

Twins Home
8-19-0 ATS
29.63% • -42.48%
9-18-0 ML (33.33%)
Guardians Home
12-18-0 ATS
40% • -32.7%
20-10-0 ML (66.67%)

Scoring Averages

Twins
4
PPG
4.1
allowed
Total
8.1
Avg
57
games
Guardians
4.1
PPG
4
allowed

Recent Matchups

DateScoreATSMLO/U
09/21W 6-2WU
09/20L 0-6LU
09/20L 0-8LU
09/19L 2-6LP
08/03W 4-5WO
08/02L 5-4LO
08/01L 3-2LU
05/21L 1-5LU
05/19W 6-5WO
05/01L 4-3LU
04/30L 4-2LU
04/29L 2-1LU
04/28W 1-11WO
09/19L 3-2LU
09/18L 5-4LO
09/17W 1-4WU
09/16L 4-3LU
08/11L 3-5LP
08/10L 1-2LU
08/09W 4-2WU

Frequently Asked Questions

What is the Minnesota Twins vs Cleveland Guardians all-time record?
The Minnesota Twins are 19-38 against the Cleveland Guardians in head-to-head matchups.
What is the Minnesota Twins ATS record vs the Cleveland Guardians?
The Minnesota Twins are 26-31-0 against the spread vs the Cleveland Guardians on DraftKings, with -13.23% ROI.
Do Minnesota Twins vs Cleveland Guardians games go over or under?
Minnesota Twins vs Cleveland Guardians games average 8.1 total points. The Over has hit 34.55% of the time.

More Twins Matchups

Head-to-head betting record for Minnesota Twins vs Cleveland Guardians on LineTerminal. The Twins are 19-38 straight up against the Guardians and 26-31-0 against the spread (45.61% cover rate, -13.23% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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