Cleveland Guardians Lead Minnesota Twins 38-19 in Head-to-Head Matchups

MLB31-26-0 ATS (54.39%)Data through 2025-09-21

Guardians vs Twins Betting Record

Against the Spread
31-26-0
Win %
54.39%
ROI
-1.84%
Units
-1.1
Moneyline
38-19-0
Win %
66.67%
ROI
+30.58%
Units
+17.4
Over Rate
19-36-2
Win %
34.55%
ROI
-33.26%
Units
-18.3

From the Other Side — Twins vs Guardians

Against the Spread
26-31-0
Win %
45.61%
ROI
-13.23%
Units
-7.5
Moneyline
19-38-0
Win %
33.33%
ROI
-38.56%
Units
-22.0
Over Rate
19-36-2
Win %
34.55%
ROI
-33.26%
Units
-18.3

Venue Splits

Guardians Home
12-18-0 ATS
40% • -32.7%
20-10-0 ML (66.67%)
Twins Home
8-19-0 ATS
29.63% • -42.48%
9-18-0 ML (33.33%)

Scoring Averages

Guardians
4.1
PPG
4
allowed
Total
8.1
Avg
57
games
Twins
4
PPG
4.1
allowed

Recent Matchups

DateScoreATSMLO/U
09/21L 6-2LU
09/20W 0-6WU
09/20W 0-8WU
09/19W 2-6WP
08/03L 4-5LO
08/02W 5-4WO
08/01W 3-2WU
05/21W 1-5WU
05/19L 6-5LO
05/01W 4-3WU
04/30W 4-2WU
04/29W 2-1WU
04/28L 1-11LO
09/19W 3-2WU
09/18W 5-4WO
09/17L 1-4LU
09/16W 4-3WU
08/11W 3-5WP
08/10W 1-2WU
08/09L 4-2LU

Frequently Asked Questions

What is the Cleveland Guardians vs Minnesota Twins all-time record?
The Cleveland Guardians are 38-19 against the Minnesota Twins in head-to-head matchups.
What is the Cleveland Guardians ATS record vs the Minnesota Twins?
The Cleveland Guardians are 31-26-0 against the spread vs the Minnesota Twins on DraftKings, with -1.84% ROI.
Do Cleveland Guardians vs Minnesota Twins games go over or under?
Cleveland Guardians vs Minnesota Twins games average 8.1 total points. The Over has hit 34.55% of the time.

More Guardians Matchups

Head-to-head betting record for Cleveland Guardians vs Minnesota Twins on LineTerminal. The Guardians are 38-19 straight up against the Twins and 31-26-0 against the spread (54.39% cover rate, -1.84% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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