Cleveland Guardians Lead Chicago White Sox 36-22 in Head-to-Head Matchups

MLB31-27-0 ATS (53.45%)Data through 2025-09-14

Guardians vs White Sox Betting Record

Against the Spread
31-27-0
Win %
53.45%
ROI
+8.08%
Units
+4.7
Moneyline
36-22-0
Win %
62.07%
ROI
+8.92%
Units
+5.2
Over Rate
25-32-1
Win %
43.86%
ROI
-17.39%
Units
-9.9

From the Other Side — White Sox vs Guardians

Against the Spread
27-31-0
Win %
46.55%
ROI
-16.14%
Units
-9.4
Moneyline
22-36-0
Win %
37.93%
ROI
-21.49%
Units
-12.5
Over Rate
25-32-1
Win %
43.86%
ROI
-17.39%
Units
-9.9

Venue Splits

Guardians Home
13-15-0 ATS
46.43% • -2.47%
18-10-0 ML (64.29%)
White Sox Home
12-18-0 ATS
40% • -26.2%
12-18-0 ML (40%)

Scoring Averages

Guardians
4.3
PPG
3.6
allowed
Total
7.9
Avg
58
games
White Sox
3.6
PPG
4.3
allowed

Recent Matchups

DateScoreATSMLO/U
09/14W 3-2WU
09/13W 3-1WU
09/12W 4-0WU
08/10L 6-4LO
08/09W 1-3WU
08/08W 5-9WO
07/13W 5-6WO
07/12W 2-6WU
07/11W 2-4WU
07/11L 5-4LO
04/10W 6-1WU
04/09W 3-2WU
04/08W 1-0WU
09/11W 4-6WO
09/10W 0-5WU
09/09W 3-5WU
07/04W 8-4WO
07/03L 2-8LO
07/02W 7-6WO
05/12W 0-7WU

Frequently Asked Questions

What is the Cleveland Guardians vs Chicago White Sox all-time record?
The Cleveland Guardians are 36-22 against the Chicago White Sox in head-to-head matchups.
What is the Cleveland Guardians ATS record vs the Chicago White Sox?
The Cleveland Guardians are 31-27-0 against the spread vs the Chicago White Sox on DraftKings, with +8.08% ROI.
Do Cleveland Guardians vs Chicago White Sox games go over or under?
Cleveland Guardians vs Chicago White Sox games average 7.9 total points. The Over has hit 43.86% of the time.

More Guardians Matchups

Head-to-head betting record for Cleveland Guardians vs Chicago White Sox on LineTerminal. The Guardians are 36-22 straight up against the White Sox and 31-27-0 against the spread (53.45% cover rate, +8.08% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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