Cleveland Guardians Lead Chicago White Sox 36-22 in Head-to-Head Matchups

MLB27-31-0 ATS (46.55%)Data through 2025-09-14

White Sox vs Guardians Betting Record

Against the Spread
27-31-0
Win %
46.55%
ROI
-16.14%
Units
-9.4
Moneyline
22-36-0
Win %
37.93%
ROI
-21.49%
Units
-12.5
Over Rate
25-32-1
Win %
43.86%
ROI
-17.39%
Units
-9.9

From the Other Side — Guardians vs White Sox

Against the Spread
31-27-0
Win %
53.45%
ROI
+8.08%
Units
+4.7
Moneyline
36-22-0
Win %
62.07%
ROI
+8.92%
Units
+5.2
Over Rate
25-32-1
Win %
43.86%
ROI
-17.39%
Units
-9.9

Venue Splits

White Sox Home
12-18-0 ATS
40% • -26.2%
12-18-0 ML (40%)
Guardians Home
13-15-0 ATS
46.43% • -2.47%
18-10-0 ML (64.29%)

Scoring Averages

White Sox
3.6
PPG
4.3
allowed
Total
7.9
Avg
58
games
Guardians
4.3
PPG
3.6
allowed

Recent Matchups

DateScoreATSMLO/U
09/14L 3-2LU
09/13L 3-1LU
09/12L 4-0LU
08/10W 6-4WO
08/09L 1-3LU
08/08L 5-9LO
07/13L 5-6LO
07/12L 2-6LU
07/11L 2-4LU
07/11W 5-4WO
04/10L 6-1LU
04/09L 3-2LU
04/08L 1-0LU
09/11L 4-6LO
09/10L 0-5LU
09/09L 3-5LU
07/04L 8-4LO
07/03W 2-8WO
07/02L 7-6LO
05/12L 0-7LU

Frequently Asked Questions

What is the Chicago White Sox vs Cleveland Guardians all-time record?
The Chicago White Sox are 22-36 against the Cleveland Guardians in head-to-head matchups.
What is the Chicago White Sox ATS record vs the Cleveland Guardians?
The Chicago White Sox are 27-31-0 against the spread vs the Cleveland Guardians on DraftKings, with -16.14% ROI.
Do Chicago White Sox vs Cleveland Guardians games go over or under?
Chicago White Sox vs Cleveland Guardians games average 7.9 total points. The Over has hit 43.86% of the time.

More White Sox Matchups

Head-to-head betting record for Chicago White Sox vs Cleveland Guardians on LineTerminal. The White Sox are 22-36 straight up against the Guardians and 27-31-0 against the spread (46.55% cover rate, -16.14% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.

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