Iowa State Cyclones Lead Oklahoma State Cowboys 2-1 in Head-to-Head Matchups

NCAAF2-1-0 ATS (66.67%)Updated November 29, 2025

The Oklahoma State Cowboys are 1-2 against the Iowa State Cyclones in head-to-head matchups, going 2-1-0 ATS (66.67% cover rate) with +26.52% ROI. Games average 42.7 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cowboys vs Cyclones Betting Record

Against the Spread

2-1-0

Win %

66.67%

ROI

+26.52%

Units

+0.8

Moneyline

1-2-0

Win %

33.33%

ROI

-31.67%

Units

-0.9

Over Rate

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

From the Other Side — Cyclones vs Cowboys

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.36%

Units

-1.1

Moneyline

2-1-0

Win %

66.67%

ROI

-8.39%

Units

-0.3

Over Rate

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

Venue Splits

Cowboys Home

2-0-0 ATS

100% • +89.77%

1-1-0 ML (50%)

Cyclones Home

1-0-0 ATS

100% • +90.91%

1-0-0 ML (100%)

Scoring Averages

Cowboys

PPG

22.7

allowed

Total

42.7

Avg

games

Cyclones

22.7

PPG

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/292025-11-29	Cyclones @ Cowboys	L 13-20	-14	✓	L	U
09/232023-09-23	Cowboys @ Cyclones	L 34-27	-3.5	✗	L	O
11/122022-11-12	Cyclones @ Cowboys	W 20-14	-2.5	✓	W	U

Frequently Asked Questions

What is the Oklahoma State Cowboys vs Iowa State Cyclones all-time record?

The Oklahoma State Cowboys are 1-2 against the Iowa State Cyclones in head-to-head matchups.

What is the Oklahoma State Cowboys ATS record vs the Iowa State Cyclones?

The Oklahoma State Cowboys are 2-1-0 against the spread vs the Iowa State Cyclones on DraftKings, with +26.52% ROI.

Do Oklahoma State Cowboys vs Iowa State Cyclones games go over or under?

Oklahoma State Cowboys vs Iowa State Cyclones games average 42.7 total points. The Over has hit 33.33% of the time.

More Cowboys Matchups

See from Cyclones perspective

Head-to-head betting record for Oklahoma State Cowboys vs Iowa State Cyclones on LineTerminal. The Cowboys are 1-2 straight up against the Cyclones and 2-1-0 against the spread (66.67% cover rate, +26.52% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.