Iowa State Cyclones Lead Oklahoma State Cowboys 2-1 in Head-to-Head Matchups

NCAAF1-2-0 ATS (33.33%)Updated November 29, 2025

The Iowa State Cyclones are 2-1 against the Oklahoma State Cowboys in head-to-head matchups, going 1-2-0 ATS (33.33% cover rate) with -36.36% ROI. Games average 42.7 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Cyclones vs Cowboys Betting Record

Against the Spread

1-2-0

Win %

33.33%

ROI

-36.36%

Units

-1.1

Moneyline

2-1-0

Win %

66.67%

ROI

-8.39%

Units

-0.3

Over Rate

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

From the Other Side — Cowboys vs Cyclones

Against the Spread

2-1-0

Win %

66.67%

ROI

+26.52%

Units

+0.8

Moneyline

1-2-0

Win %

33.33%

ROI

-31.67%

Units

-0.9

Over Rate

1-2-0

Win %

33.33%

ROI

-36.9%

Units

-1.1

Venue Splits

Cyclones Home

1-0-0 ATS

100% • +90.91%

1-0-0 ML (100%)

Cowboys Home

2-0-0 ATS

100% • +89.77%

1-1-0 ML (50%)

Scoring Averages

Cyclones

22.7

PPG

allowed

Total

42.7

Avg

games

Cowboys

PPG

22.7

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
11/292025-11-29	Cyclones @ Cowboys	W 13-20	-14	✗	W	U
09/232023-09-23	Cowboys @ Cyclones	W 34-27	-3.5	✓	W	O
11/122022-11-12	Cyclones @ Cowboys	L 20-14	-2.5	✗	L	U

Frequently Asked Questions

What is the Iowa State Cyclones vs Oklahoma State Cowboys all-time record?

The Iowa State Cyclones are 2-1 against the Oklahoma State Cowboys in head-to-head matchups.

What is the Iowa State Cyclones ATS record vs the Oklahoma State Cowboys?

The Iowa State Cyclones are 1-2-0 against the spread vs the Oklahoma State Cowboys on DraftKings, with -36.36% ROI.

Do Iowa State Cyclones vs Oklahoma State Cowboys games go over or under?

Iowa State Cyclones vs Oklahoma State Cowboys games average 42.7 total points. The Over has hit 33.33% of the time.

More Cyclones Matchups

See from Cowboys perspective

Head-to-head betting record for Iowa State Cyclones vs Oklahoma State Cowboys on LineTerminal. The Cyclones are 2-1 straight up against the Cowboys and 1-2-0 against the spread (33.33% cover rate, -36.36% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.