Indiana Hoosiers Lead Michigan State Spartans 3-1 in Head-to-Head Matchups

NCAAF2-2-0 ATS (50%)Updated October 18, 2025

The Michigan State Spartans are 1-3 against the Indiana Hoosiers in head-to-head matchups, going 2-2-0 ATS (50% cover rate) with -4.53% ROI. Games average 55.8 total points. Closing lines from DraftKings, FanDuel, and BetMGM, graded against official NCAAF box scores.

See methodology.

Spartans vs Hoosiers Betting Record

Against the Spread

2-2-0

Win %

50%

ROI

-4.53%

Units

-0.2

Moneyline

1-3-0

Win %

25%

ROI

-37.5%

Units

-1.5

Over Rate

3-1-0

Win %

75%

ROI

+42.61%

Units

+1.7

From the Other Side — Hoosiers vs Spartans

Against the Spread

2-2-0

Win %

50%

ROI

-4.55%

Units

-0.2

Moneyline

3-1-0

Win %

75%

ROI

+71.39%

Units

+2.9

Over Rate

3-1-0

Win %

75%

ROI

+42.61%

Units

+1.7

Venue Splits

Spartans Home

0-2-0 ATS

0% • -100%

0-2-0 ML (0%)

Hoosiers Home

0-2-0 ATS

0% • -100%

1-1-0 ML (50%)

Scoring Averages

Spartans

19.5

PPG

36.3

allowed

Total

55.8

Avg

games

Hoosiers

36.3

PPG

19.5

allowed

Recent Matchups

Date	Matchup	Score	Spread	ATS	ML	O/U
10/182025-10-18	Spartans @ Hoosiers	L 38-13	-26.5	✓	L	O
11/022024-11-02	Hoosiers @ Spartans	L 10-47	-7.5	✗	L	O
11/182023-11-18	Spartans @ Hoosiers	W 21-24	-3.5	✓	W	U
11/192022-11-19	Hoosiers @ Spartans	L 31-39	-12	✗	L	O

Frequently Asked Questions

What is the Michigan State Spartans vs Indiana Hoosiers all-time record?

The Michigan State Spartans are 1-3 against the Indiana Hoosiers in head-to-head matchups.

What is the Michigan State Spartans ATS record vs the Indiana Hoosiers?

The Michigan State Spartans are 2-2-0 against the spread vs the Indiana Hoosiers on DraftKings, with -4.53% ROI.

Do Michigan State Spartans vs Indiana Hoosiers games go over or under?

Michigan State Spartans vs Indiana Hoosiers games average 55.8 total points. The Over has hit 75% of the time.

More Spartans Matchups

See from Hoosiers perspective

Head-to-head betting record for Michigan State Spartans vs Indiana Hoosiers on LineTerminal. The Spartans are 1-3 straight up against the Hoosiers and 2-2-0 against the spread (50% cover rate, -4.53% ROI) on DraftKings. Data sourced from DraftKings closing lines. Updated daily after games are graded. Past performance does not guarantee future results.